Valorization of guabirobeira leaf extracts (Campomanesia xanthocarpa) through pressurized liquid extraction and aqueous infusion: assessment of phytochemical composition, antibacterial, and antioxidant activities

• Published in: Journal of chemical technology and biotechnology (1986) 2024-08, Vol.99 (8), p.1763-1778
• Main Authors: Bagatini, Lucíola, Fischer, Bruno, Zandoná, Giovana Paula, Moroni, Liziane Schittler, Junges, Alexander, Kempka, Aniela Pinto, Rombaldi, Cesar Valmor
• Format: Article
• Language: English
• Subjects: antibacterial; Antibacterial activity; Antiinfectives and antibacterials; antioxidant; Antioxidants; Bacteria; Beverages; Bioactive compounds; Brain; Chemical activity; Chemical composition; Chemical compounds; Cosmetics; Ethanol; Flavonoids; Functional materials; Gram-negative bacteria; Green chemistry; Inflammation; Leaves; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Pain perception; Phenolic compounds; Phenols; phytochemical compounds; Phytochemicals; Plant extracts; Preservatives; pressurized liquid; Reactive oxygen species; Sustainable practices; Thiobarbituric acid
• ISSN: 0268-2575; 1097-4660
• DOI: 10.1002/jctb.7663

BACKGROUND The leaves of guabirobeira contain important phenolic and flavonoid compounds, known for their antioxidant, anti‐inflammatory, antibacterial, and antinociceptive activities. The purpose of this work was to obtain extracts from guabirobeira leaves through aqueous infusion and pressurized liquid extraction with water, ethanol, and a combination of water–ethanol (ratio 1:1, v/v; PLE‐W:E). Subsequently, we used liquid chromatography coupled with mass spectrometry to identify the chemical compounds, and to study the antioxidant activity in rat brain cells; thiobarbituric acid reactive substances (TBARS) and reactive oxygen species (ROS) antibacterial activity against Gram‐negative and Gram‐positive bacteria were also seen. RESULTS According to the findings, all four extracts contained a significant amount of phytochemical compounds. Among them, the PLE‐W:E extract showed a higher concentration of flavonoids, demonstrating significant antioxidant activity in in vitro assays of TBARS and ROS in rat brain cells. It also exhibited antibacterial activity against both Gram‐positive and Gram‐negative bacteria. CONCLUSION Guabirobeira leaf extracts hold promise as a potential source of bioactive compounds. These extracts can be applied across various sectors, including cosmetics and skincare products, pharmaceuticals, food and beverages, natural preservatives, and functional materials. By exploring these potential applications, valuable contributions can be made to the field of sustainable chemistry and pharmacy, furthering the utilization of guabirobeira leaf extracts in diverse industries. This approach also aligns with the promotion of environmentally friendly and sustainable practices. © 2024 Society of Chemical Industry (SCI).