New monoterpenoid indole alkaloids from the stems of Tabernaemontana bovina Lour (Apocynaceae)

Two new monoterpenoid indole alkaloids, named taberibogines E and F (1 and 2), together with three known ones (3-5) were isolated from the stems of Tabernaemontana bovina Lour (Apocynaceae). Their structures including absolute configurations were elucidated from a combination of NMR and HRESIMS data...

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Bibliographic Details
Published in:Natural product research 2024-07, Vol.38 (14), p.2447-2452
Main Authors: Yan, Xue-Wei, Du, Si-Yu, Wang, Xiao-Tong, Zhu, Kong-Kai, Fang, Lei
Format: Article
Language:English
Subjects:
Alkaloids
anti-inflammatory activity
Apocynaceae
Macrophages
monoterpenoid indole alkaloids
Nitric oxide
NMR
Nuclear magnetic resonance
Tabernaemontana
Tabernaemontana bovina Lour
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Summary:Two new monoterpenoid indole alkaloids, named taberibogines E and F (1 and 2), together with three known ones (3-5) were isolated from the stems of Tabernaemontana bovina Lour (Apocynaceae). Their structures including absolute configurations were elucidated from a combination of NMR and HRESIMS data and NMR calculations as well as DP4+ probability analyses. Compounds 1 and 2 exhibited inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages.
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2023.2180503