Investigation of bioactivities of methanolic and ethyl acetate extracts of Dioscorea pentaphylla leaf along with its phenolic composition

The present study was performed to investigate the in-vitro antioxidant properties, brine shrimp lethality bioassay, and antimicrobial activity and in-vivo analgesic, anti-inflammatory, and antidiarrheal potentiality of methanolic and ethyl acetate extracts of Dioscorea pentaphylla ( D. pentaphylla...

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Bibliographic Details
Published in:Journal of food measurement & characterization 2019-03, Vol.13 (1), p.622-633
Main Authors: Mondal, Milon, Hossain, Md. Monir, Das, Nittananda, Rahman, Mohammad Asikur, Uddin, Nizam, Hasan, Md. Rakib, Alam, Md. Jahir, Islam, Md. Nurul, Wahed, Tania Binte, Kundu, Sukalyan Kumar
Format: Article
Language:English
Subjects:
Acetic acid
Analgesics
Antimicrobial activity
Antimicrobial agents
Antioxidants
Bioassays
Biological activity
Brines
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Deodorants
Diarrhea
Dioscorea pentaphylla
Edema
Engineering
Ethyl acetate
Flavonoids
Food Science
Gallic acid
Granuloma
High-performance liquid chromatography
Inflammation
Investigations
Leaves
Lethality
Liquid chromatography
Methanol
Nitric oxide
Original Paper
Pain perception
Phenols
Plant extracts
Quercetin
Rutin
Scavenging
Shrimps
Xylene
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Summary:The present study was performed to investigate the in-vitro antioxidant properties, brine shrimp lethality bioassay, and antimicrobial activity and in-vivo analgesic, anti-inflammatory, and antidiarrheal potentiality of methanolic and ethyl acetate extracts of Dioscorea pentaphylla ( D. pentaphylla ) leaf along with determining the bioactive phenolic compounds by HPLC analysis. Standard methods were used to investigate the aforementioned bioactivities. Methanol extract showed higher total phenolic activity, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and Nitric oxide (NO) radical scavenging activities, whereas ethyl acetate extract showed better activities in total flavonoid and total antioxidant capacity assays. Dose-dependent moderate reducing capacity was observed for both extracts in cupric reducing and reducing power capacity assays. The methanol extract was found to be more potent than ethyl acetate extract according to brine shrimp lethality bioactivity test. Both extracts exhibited broad-spectrum antimicrobial activity in the disk diffusion method. In tail immersion test, at 1000 mg/kg dose, both extracts of D. pentaphylla showed a significant ( p  
ISSN:2193-4126
2193-4134
DOI:10.1007/s11694-018-9975-1