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Investigation of bioactivities of methanolic and ethyl acetate extracts of Dioscorea pentaphylla leaf along with its phenolic composition
The present study was performed to investigate the in-vitro antioxidant properties, brine shrimp lethality bioassay, and antimicrobial activity and in-vivo analgesic, anti-inflammatory, and antidiarrheal potentiality of methanolic and ethyl acetate extracts of Dioscorea pentaphylla ( D. pentaphylla...
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| Published in: | Journal of food measurement & characterization 2019-03, Vol.13 (1), p.622-633 |
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| creator | Mondal, Milon Hossain, Md. Monir Das, Nittananda Rahman, Mohammad Asikur Uddin, Nizam Hasan, Md. Rakib Alam, Md. Jahir Islam, Md. Nurul Wahed, Tania Binte Kundu, Sukalyan Kumar |
| description | The present study was performed to investigate the in-vitro antioxidant properties, brine shrimp lethality bioassay, and antimicrobial activity and in-vivo analgesic, anti-inflammatory, and antidiarrheal potentiality of methanolic and ethyl acetate extracts of
Dioscorea pentaphylla
(
D. pentaphylla
) leaf along with determining the bioactive phenolic compounds by HPLC analysis. Standard methods were used to investigate the aforementioned bioactivities. Methanol extract showed higher total phenolic activity, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and Nitric oxide (NO) radical scavenging activities, whereas ethyl acetate extract showed better activities in total flavonoid and total antioxidant capacity assays. Dose-dependent moderate reducing capacity was observed for both extracts in cupric reducing and reducing power capacity assays. The methanol extract was found to be more potent than ethyl acetate extract according to brine shrimp lethality bioactivity test. Both extracts exhibited broad-spectrum antimicrobial activity in the disk diffusion method. In tail immersion test, at 1000 mg/kg dose, both extracts of
D. pentaphylla
showed a significant (
p
|
| doi_str_mv | 10.1007/s11694-018-9975-1 |
| format | article |
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Dioscorea pentaphylla
(
D. pentaphylla
) leaf along with determining the bioactive phenolic compounds by HPLC analysis. Standard methods were used to investigate the aforementioned bioactivities. Methanol extract showed higher total phenolic activity, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and Nitric oxide (NO) radical scavenging activities, whereas ethyl acetate extract showed better activities in total flavonoid and total antioxidant capacity assays. Dose-dependent moderate reducing capacity was observed for both extracts in cupric reducing and reducing power capacity assays. The methanol extract was found to be more potent than ethyl acetate extract according to brine shrimp lethality bioactivity test. Both extracts exhibited broad-spectrum antimicrobial activity in the disk diffusion method. In tail immersion test, at 1000 mg/kg dose, both extracts of
D. pentaphylla
showed a significant (
p
< 0.05) reduction in pain sensation. Ethyl acetate extract has significantly (
p
< 0.05) decreased writhing of the tested mice which were induced by acetic acid. The number of licks in formalin-induced paw licking test was markedly (
p
< 0.05) lessened in both extracts administration. Ethyl acetate extract revealed better anti-inflammatory activities than methanol extract in two well-known anti-inflammatory models (Xylene-induced ear edema, Cotton pellet-induced granuloma formation). Methanol extract displayed potent anti-diarrheal activity. HPLC analysis confirmed the existence of phenolic compounds (gallic acid, rutin, and quercetin) in the leaf extract of
D. pentaphylla
. These phytochemical constituents might have the role in the observed activities.</description><identifier>ISSN: 2193-4126</identifier><identifier>EISSN: 2193-4134</identifier><identifier>DOI: 10.1007/s11694-018-9975-1</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acetic acid ; Analgesics ; Antimicrobial activity ; Antimicrobial agents ; Antioxidants ; Bioassays ; Biological activity ; Brines ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Deodorants ; Diarrhea ; Dioscorea pentaphylla ; Edema ; Engineering ; Ethyl acetate ; Flavonoids ; Food Science ; Gallic acid ; Granuloma ; High-performance liquid chromatography ; Inflammation ; Investigations ; Leaves ; Lethality ; Liquid chromatography ; Methanol ; Nitric oxide ; Original Paper ; Pain perception ; Phenols ; Plant extracts ; Quercetin ; Rutin ; Scavenging ; Shrimps ; Xylene</subject><ispartof>Journal of food measurement & characterization, 2019-03, Vol.13 (1), p.622-633</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-d6a01bbd261fc547f10118642a04ddbcab1c65d59550bab1e347b016288512293</citedby><cites>FETCH-LOGICAL-c316t-d6a01bbd261fc547f10118642a04ddbcab1c65d59550bab1e347b016288512293</cites><orcidid>0000-0002-6342-2820</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3078653038?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,44590</link.rule.ids></links><search><creatorcontrib>Mondal, Milon</creatorcontrib><creatorcontrib>Hossain, Md. Monir</creatorcontrib><creatorcontrib>Das, Nittananda</creatorcontrib><creatorcontrib>Rahman, Mohammad Asikur</creatorcontrib><creatorcontrib>Uddin, Nizam</creatorcontrib><creatorcontrib>Hasan, Md. Rakib</creatorcontrib><creatorcontrib>Alam, Md. Jahir</creatorcontrib><creatorcontrib>Islam, Md. Nurul</creatorcontrib><creatorcontrib>Wahed, Tania Binte</creatorcontrib><creatorcontrib>Kundu, Sukalyan Kumar</creatorcontrib><title>Investigation of bioactivities of methanolic and ethyl acetate extracts of Dioscorea pentaphylla leaf along with its phenolic composition</title><title>Journal of food measurement & characterization</title><addtitle>Food Measure</addtitle><description>The present study was performed to investigate the in-vitro antioxidant properties, brine shrimp lethality bioassay, and antimicrobial activity and in-vivo analgesic, anti-inflammatory, and antidiarrheal potentiality of methanolic and ethyl acetate extracts of
Dioscorea pentaphylla
(
D. pentaphylla
) leaf along with determining the bioactive phenolic compounds by HPLC analysis. Standard methods were used to investigate the aforementioned bioactivities. Methanol extract showed higher total phenolic activity, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and Nitric oxide (NO) radical scavenging activities, whereas ethyl acetate extract showed better activities in total flavonoid and total antioxidant capacity assays. Dose-dependent moderate reducing capacity was observed for both extracts in cupric reducing and reducing power capacity assays. The methanol extract was found to be more potent than ethyl acetate extract according to brine shrimp lethality bioactivity test. Both extracts exhibited broad-spectrum antimicrobial activity in the disk diffusion method. In tail immersion test, at 1000 mg/kg dose, both extracts of
D. pentaphylla
showed a significant (
p
< 0.05) reduction in pain sensation. Ethyl acetate extract has significantly (
p
< 0.05) decreased writhing of the tested mice which were induced by acetic acid. The number of licks in formalin-induced paw licking test was markedly (
p
< 0.05) lessened in both extracts administration. Ethyl acetate extract revealed better anti-inflammatory activities than methanol extract in two well-known anti-inflammatory models (Xylene-induced ear edema, Cotton pellet-induced granuloma formation). Methanol extract displayed potent anti-diarrheal activity. HPLC analysis confirmed the existence of phenolic compounds (gallic acid, rutin, and quercetin) in the leaf extract of
D. pentaphylla
. These phytochemical constituents might have the role in the observed activities.</description><subject>Acetic acid</subject><subject>Analgesics</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Antioxidants</subject><subject>Bioassays</subject><subject>Biological activity</subject><subject>Brines</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Deodorants</subject><subject>Diarrhea</subject><subject>Dioscorea pentaphylla</subject><subject>Edema</subject><subject>Engineering</subject><subject>Ethyl acetate</subject><subject>Flavonoids</subject><subject>Food Science</subject><subject>Gallic acid</subject><subject>Granuloma</subject><subject>High-performance liquid chromatography</subject><subject>Inflammation</subject><subject>Investigations</subject><subject>Leaves</subject><subject>Lethality</subject><subject>Liquid chromatography</subject><subject>Methanol</subject><subject>Nitric oxide</subject><subject>Original Paper</subject><subject>Pain perception</subject><subject>Phenols</subject><subject>Plant extracts</subject><subject>Quercetin</subject><subject>Rutin</subject><subject>Scavenging</subject><subject>Shrimps</subject><subject>Xylene</subject><issn>2193-4126</issn><issn>2193-4134</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kMtOwzAQRS0EElXpB7CzxDrgsR0nWaLyqlSJDawtx3FaV2kcbLfQT-CvcQmCFat56Nw7movQJZBrIKS4CQCi4hmBMquqIs_gBE0oVCzjwPjpb0_FOZqFsCGEABScCzZBn4t-b0K0KxWt67FrcW2d0tHubbQmHBdbE9eqd53VWPUNTtOhw0qbqKLB5iP6hH-Dd9YF7bxReDB9VEPiOoU7o1qsOtev8LuNa2wTPKzNaKjddnDBHm9foLNWdcHMfuoUvT7cv8yfsuXz42J-u8w0AxGzRigCdd1QAa3OedFCeqYUnCrCm6bWqgYt8iav8pzUaTCMFzUBQcsyB0orNkVXo-_g3dsu_S43buf7dFIyUpQiZ4SViYKR0t6F4E0rB2-3yh8kEHkMXY6hyxS6PIYuIWnoqAmJ7VfG_zn_L_oCc-GG9A</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Mondal, Milon</creator><creator>Hossain, Md. Monir</creator><creator>Das, Nittananda</creator><creator>Rahman, Mohammad Asikur</creator><creator>Uddin, Nizam</creator><creator>Hasan, Md. Rakib</creator><creator>Alam, Md. Jahir</creator><creator>Islam, Md. Nurul</creator><creator>Wahed, Tania Binte</creator><creator>Kundu, Sukalyan Kumar</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>M0K</scope><scope>M7S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><orcidid>https://orcid.org/0000-0002-6342-2820</orcidid></search><sort><creationdate>20190301</creationdate><title>Investigation of bioactivities of methanolic and ethyl acetate extracts of Dioscorea pentaphylla leaf along with its phenolic composition</title><author>Mondal, Milon ; Hossain, Md. Monir ; Das, Nittananda ; Rahman, Mohammad Asikur ; Uddin, Nizam ; Hasan, Md. Rakib ; Alam, Md. Jahir ; Islam, Md. Nurul ; Wahed, Tania Binte ; Kundu, Sukalyan Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-d6a01bbd261fc547f10118642a04ddbcab1c65d59550bab1e347b016288512293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetic acid</topic><topic>Analgesics</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Antioxidants</topic><topic>Bioassays</topic><topic>Biological activity</topic><topic>Brines</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Deodorants</topic><topic>Diarrhea</topic><topic>Dioscorea pentaphylla</topic><topic>Edema</topic><topic>Engineering</topic><topic>Ethyl acetate</topic><topic>Flavonoids</topic><topic>Food Science</topic><topic>Gallic acid</topic><topic>Granuloma</topic><topic>High-performance liquid chromatography</topic><topic>Inflammation</topic><topic>Investigations</topic><topic>Leaves</topic><topic>Lethality</topic><topic>Liquid chromatography</topic><topic>Methanol</topic><topic>Nitric oxide</topic><topic>Original Paper</topic><topic>Pain perception</topic><topic>Phenols</topic><topic>Plant extracts</topic><topic>Quercetin</topic><topic>Rutin</topic><topic>Scavenging</topic><topic>Shrimps</topic><topic>Xylene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mondal, Milon</creatorcontrib><creatorcontrib>Hossain, Md. Monir</creatorcontrib><creatorcontrib>Das, Nittananda</creatorcontrib><creatorcontrib>Rahman, Mohammad Asikur</creatorcontrib><creatorcontrib>Uddin, Nizam</creatorcontrib><creatorcontrib>Hasan, Md. Rakib</creatorcontrib><creatorcontrib>Alam, Md. Jahir</creatorcontrib><creatorcontrib>Islam, Md. 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Monir</au><au>Das, Nittananda</au><au>Rahman, Mohammad Asikur</au><au>Uddin, Nizam</au><au>Hasan, Md. Rakib</au><au>Alam, Md. Jahir</au><au>Islam, Md. Nurul</au><au>Wahed, Tania Binte</au><au>Kundu, Sukalyan Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of bioactivities of methanolic and ethyl acetate extracts of Dioscorea pentaphylla leaf along with its phenolic composition</atitle><jtitle>Journal of food measurement & characterization</jtitle><stitle>Food Measure</stitle><date>2019-03-01</date><risdate>2019</risdate><volume>13</volume><issue>1</issue><spage>622</spage><epage>633</epage><pages>622-633</pages><issn>2193-4126</issn><eissn>2193-4134</eissn><abstract>The present study was performed to investigate the in-vitro antioxidant properties, brine shrimp lethality bioassay, and antimicrobial activity and in-vivo analgesic, anti-inflammatory, and antidiarrheal potentiality of methanolic and ethyl acetate extracts of
Dioscorea pentaphylla
(
D. pentaphylla
) leaf along with determining the bioactive phenolic compounds by HPLC analysis. Standard methods were used to investigate the aforementioned bioactivities. Methanol extract showed higher total phenolic activity, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and Nitric oxide (NO) radical scavenging activities, whereas ethyl acetate extract showed better activities in total flavonoid and total antioxidant capacity assays. Dose-dependent moderate reducing capacity was observed for both extracts in cupric reducing and reducing power capacity assays. The methanol extract was found to be more potent than ethyl acetate extract according to brine shrimp lethality bioactivity test. Both extracts exhibited broad-spectrum antimicrobial activity in the disk diffusion method. In tail immersion test, at 1000 mg/kg dose, both extracts of
D. pentaphylla
showed a significant (
p
< 0.05) reduction in pain sensation. Ethyl acetate extract has significantly (
p
< 0.05) decreased writhing of the tested mice which were induced by acetic acid. The number of licks in formalin-induced paw licking test was markedly (
p
< 0.05) lessened in both extracts administration. Ethyl acetate extract revealed better anti-inflammatory activities than methanol extract in two well-known anti-inflammatory models (Xylene-induced ear edema, Cotton pellet-induced granuloma formation). Methanol extract displayed potent anti-diarrheal activity. HPLC analysis confirmed the existence of phenolic compounds (gallic acid, rutin, and quercetin) in the leaf extract of
D. pentaphylla
. These phytochemical constituents might have the role in the observed activities.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11694-018-9975-1</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6342-2820</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of food measurement & characterization, 2019-03, Vol.13 (1), p.622-633 |
| issn | 2193-4126 2193-4134 |
| language | eng |
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| source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); Springer Nature |
| subjects | Acetic acid Analgesics Antimicrobial activity Antimicrobial agents Antioxidants Bioassays Biological activity Brines Chemistry Chemistry and Materials Science Chemistry/Food Science Deodorants Diarrhea Dioscorea pentaphylla Edema Engineering Ethyl acetate Flavonoids Food Science Gallic acid Granuloma High-performance liquid chromatography Inflammation Investigations Leaves Lethality Liquid chromatography Methanol Nitric oxide Original Paper Pain perception Phenols Plant extracts Quercetin Rutin Scavenging Shrimps Xylene |
| title | Investigation of bioactivities of methanolic and ethyl acetate extracts of Dioscorea pentaphylla leaf along with its phenolic composition |
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