PP-068 A case of vaccination of a child with Hutchinson-Gilford syndrome

• Published in: BMJ paediatrics open 2024-07, Vol.8 (Suppl 5), p.A93-A93
• Main Authors: Kaliuzhnaia, Tatiana, Fedoseenko, Marina, Shakhtakhtinskaya, Firuza, Selvian, Arevaluis, Tolstova, Svetlana, Namazova-Baranova, Leyla
• Format: Article
• Language: English
• Subjects: Antibodies; effectiveness; Hepatitis; Hutchinson-Gilford syndrome; Immunization; Measles; Mumps; Pediatrics; Poster Presentation; protection; Rubella; Tetanus; vaccination; Vaccines; Whooping cough
• ISSN: 2399-9772
• DOI: 10.1136/bmjpo-2024-EPAC.212

AimTo evaluate the effectiveness and safety of vaccination of a patient with Hutchinson-Gilford syndrome, as well as to form a personalized approach to immunization for children with this syndrome.Material and MethodAt the reception a 10-year-old boy with a diagnosis of Hutchinson-Gilford syndrome. He was not ill with childhood infections. Preventive vaccinations were carried out after a year with irregular intervals (due to previously issued medical withdrawal) with vaccines of domestic and foreign production (Order of the Ministry of Health of the Russian Federation N 125N of 21.03.2014 ) against tuberculosis, hepatitis B, whooping cough, diphtheria, tetanus, polio, hemophilus influenzae type B, measles, rubella and mumps, pneumococcal infection. The post-vaccination period, according to the parents, proceeded satisfactorily. During the study, revaccination was carried out against whooping cough, diphtheria, tetanus, measles, rubella, mumps, as well as additional vaccination against meningococcal infection and hepatitis A.ResultsWhile carrying out preventive vaccinations, the post-vaccination period proceeded smoothly. After completing the vaccination course, a protective level of antibodies to whooping cough (46 IU/ml), tetanus (73 IU/ml), as well as measles (3.49 CP) and rubella (164 IU/ml) was detected (table 1). There is an insufficient titer of antibodies to mumps (0.9 CP) and a negative titer of antibodies to chickenpox, which requires additional vaccination. Additional immunization with the 23-valent pneumococcal polysaccharide vaccine is also recommended for patients at risk group.Abstract PP-068 Table 1Antibody levels before and after immunizationConclusionsA patient with Hutchinson-Gilford syndrome revealed a violation of the vaccination history and immunological vulnerability according to the results of serological examination for mumps and chickenpox. The tolerability of various types of vaccines is marked by a high safety profile.