Evaluation of Antimicrobial and Analgesic Activity of Sodium Salts of 1-Aryl-4,4,4-trifluorobutane-1,3-diones

The antibacterial, antifungal, and analgesic activities of compounds of several sodium salts of 1-aryl-4,4,4-trifluorobutane-1,3-diones have been studied. These compounds have been found to exhibit a pronounced effect on Candida albicans (minimum inhibitory concentration, 7.8–62.5 μg/mL). The studie...

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Bibliographic Details
Published in:Russian journal of general chemistry 2024-05, Vol.94 (5), p.1019-1023
Main Authors: Kozlova, E. P., Balandina, S. Yu, Makhmudov, K. K., Lisovenko, N. Yu
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Aromatic compounds
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Diketones
E coli
Fungicides
Sodium salts
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Summary:The antibacterial, antifungal, and analgesic activities of compounds of several sodium salts of 1-aryl-4,4,4-trifluorobutane-1,3-diones have been studied. These compounds have been found to exhibit a pronounced effect on Candida albicans (minimum inhibitory concentration, 7.8–62.5 μg/mL). The studied compounds showed significant antibacterial activity against cultures of Staphylococcus aureus (minimum inhibitory concentration, 2.0–31.2 μg/mL) and Escherichia coli (minimum inhibitory concentration 7.8–250.0 μg/mL). In addition, all compounds have pronounced analgesic activity, which exceeds that of the reference drug (metamizole sodium).
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363224050013