Synthesis of azachalcone derivatives from cinnamaldehyde and its antibacterial activity

Cinnamaldehyde is an aromatic aldehyde compound with benzene and pyridine groups linked by aliphatic carbon atoms. These polyphenolic compounds are widely contained in the cinnamon plant and are the compounds that give the cinnamon plant its aroma and taste. Cinnamaldehyde has characteristics with b...

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Bibliographic Details
Main Authors: Amaliyah, Laely, Cahyana, Antonius Herry
Format: Conference Proceeding
Language:English
Subjects:
Aldehydes
Antidiabetics
Antiinfectives and antibacterials
Aromatic compounds
Benzaldehyde
Benzene
Biological activity
Biological effects
Carbonyl compounds
Carbonyls
Chemical synthesis
Cinnamaldehyde
Condensates
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Summary:Cinnamaldehyde is an aromatic aldehyde compound with benzene and pyridine groups linked by aliphatic carbon atoms. These polyphenolic compounds are widely contained in the cinnamon plant and are the compounds that give the cinnamon plant its aroma and taste. Cinnamaldehyde has characteristics with benzaldehyde, which is thought to have a variety of biological and pharmaceutical effects, including anti-inflammatory, antibacterial, antidiabetic, and anti-cancer qualities. The presence of an aldehyde group in this compound allows it to react with other carbonyl compounds to form a new compound such as chalcone. Many researchers have proven that chalcone is an anticancer, antidiabetic, antitumor, antibacterial, and antioxidant agent. The method used to synthesize chalcone is by reacting cinnamaldehyde with 3-acetylpiridine through the Claisen-Smith condensation reaction. The synthesis results were then characterized using TLC, UV-Vis, FTIR, and LCMS to determine the purity of the product formed. The results show that the synthesis of chalcone from cinnamaldehyde has been successfully formed.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0205081