Air pollution and incident sarcoidosis in central Pennsylvania

Sarcoidosis is a chronic granulomatous disease predominantly affecting the lungs and inducing significant morbidity and elevated mortality rate. The etiology of the disease is unknown but may involve exposure to an antigenic agent and subsequent inflammatory response resulting in granuloma formation...

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Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2024-10, Vol.87 (19), p.763-772
Main Authors: Yanosky, Jeff D., Washington, Abigail, Foulke, Galen T., Guck, Daniel, Butt, Melissa, Helm, Matthew F.
Format: Article
Language:English
Subjects:
2.5
Adult
Aged
Air Pollutants - adverse effects
Air Pollutants - analysis
Air pollution
Air Pollution - adverse effects
Air quality
Animal breeding
Case-Control Studies
Chronic granulomatous disease
Disease control
Electronic health records
Electronic medical records
elemental carbon
environmental epidemiology
Environmental Exposure - adverse effects
Exposure
Female
Granuloma
Health promotion
Humans
Incidence
Inflammatory response
Insecticides
Latency
Lung diseases
Male
Middle Aged
Morbidity
Occupational exposure
Outdoor air quality
Particulate emissions
Particulate matter
Particulate Matter - adverse effects
Particulate Matter - analysis
Pennsylvania - epidemiology
Public health
Regression analysis
Risk factors
Sarcoidosis
Sarcoidosis - chemically induced
Sarcoidosis - epidemiology
Sarcoidosis - etiology
Statistical analysis
Citations: Items that this one cites
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Description
Summary:Sarcoidosis is a chronic granulomatous disease predominantly affecting the lungs and inducing significant morbidity and elevated mortality rate. The etiology of the disease is unknown but may involve exposure to an antigenic agent and subsequent inflammatory response resulting in granuloma formation. Various environmental and occupational risk factors have been suggested by previous observations, such as moldy environments, insecticides, and bird breeding. Our study investigated the association of air pollution with diagnosis of sarcoidosis using a case-control design. Penn State Health electronic medical records from 2005 to 2018 were examined for adult patients with (cases) and without (controls) an International Classification of Disease (ICD)-9 or −10 code for sarcoidosis. Patient addresses were geocoded and 24-hr residential-level air pollution concentrations were estimated using spatio-temporal models of particulate matter 
ISSN:1528-7394
1087-2620
2381-3504
DOI:10.1080/15287394.2024.2369255