Photocatalytic Structures for Protein Modifications

The chemical modification of proteins serves as a fundamental tool for understanding biological processes and enables the design of biofunctional materials. Among the available methodologies, photochemical strategies have garnered significant attention because of their remarkable biocompatibility an...

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Bibliographic Details
Published in:ChemCatChem 2024-07, Vol.16 (14), p.n/a
Main Authors: Liu, Zhengyi, Okamoto, Yasunori, Sato, Shinichi
Format: Article
Language:English
Subjects:
Biocompatibility
Biological activity
Biological properties
Catalysts
Chemical reactions
Electron transfer
Energy transfer
Genetic code
Photocatalysis
photocatalyst
Photocatalysts
Photochemical reactions
Photoredox catalysis
protein chemical modification
protein labeling
Proteins
Reaction control
singlet electron transfer
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Summary:The chemical modification of proteins serves as a fundamental tool for understanding biological processes and enables the design of biofunctional materials. Among the available methodologies, photochemical strategies have garnered significant attention because of their remarkable biocompatibility and precise spatiotemporal reaction control. Developing novel reactions tailored to specific applications necessitates a comprehensive understanding of photoreactive properties, including catalyst structures, appropriate modifiers, and reaction conditions. This review discusses chemical modifications of proteins using an array of catalysts, including photoredox catalysts for single‐electron transfer (SET), catalysts for energy transfer, long‐wavelength excitable photocatalysts, genetically encoded photocatalysts, and artificial metalloenzymes. The discussion covers the unique attributes, mechanisms, practical applications, and future prospects of each catalyst‐driven reaction, shedding light on the evolving landscape of protein chemical modifications. This review delves into photochemical strategies, which have gained attention for their biocompatibility and precision. It explores various catalysts, including photoredox catalysts, energy transfer catalysts, and genetically encoded photocatalysts, shedding light on their unique attributes, mechanisms, applications, and future potential. This comprehensive analysis illuminates the exciting developments in protein chemical modifications.
ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.202301424