Efficient one-pot synthesis of 3-arylmethyl indoles promoted by (Bu3Sn)2MoO4 as a reusable catalyst

An efficient multi-component protocol for synthesizing substituted 3-arylmethyl indoles derivatives through a three-component strategy using water: ethanol (H 2 O:EtOH) at 45–50°C with good to excellent yields. The main advantages of this protocol are mild reaction conditions, easy workup, and recyc...

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Bibliographic Details
Published in:Journal of chemical sciences (Bangalore, India) India), 2024-07, Vol.136 (3), Article 54
Main Authors: Yakkanti, Chiranjeevi, Lakinani, Vaikunta Rao, Burra, Sathish Kumar, Gorle, Simhachalam, Venkateswarlu, R, Akula, Raghunadh
Format: Article
Language:English
Subjects:
Catalysts
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Ethanol
Indoles
Recyclability
Regular Article
Substitutes
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Summary:An efficient multi-component protocol for synthesizing substituted 3-arylmethyl indoles derivatives through a three-component strategy using water: ethanol (H 2 O:EtOH) at 45–50°C with good to excellent yields. The main advantages of this protocol are mild reaction conditions, easy workup, and recyclability of the catalyst for up to four catalytic cycles. Graphical abstract Synopsis: Synthesis of substituted 3-arylmethyl indoles by using efficient multi-component strategy in ethanol: water as a solvent system by using (Bu 3 Sn) 2 MoO 4 as a reusable catalyst at 45–50 °C with good to excellent yields. The catalyst is reusable in four catalytic cycles.
ISSN:0973-7103
0974-3626
0973-7103
DOI:10.1007/s12039-024-02289-z