A Voltammetric Sensor Based on Carbon Fiber Paper Modified with Shungite and Copper Formazanate for the Determination of Lidocaine

• Published in: Journal of analytical chemistry (New York, N.Y.) N.Y.), 2024-07, Vol.79 (7), p.848-859
• Main Authors: Bukharinova, M. A., Stozhko, N. Yu, Fedorchenko, T. G., Lipunova, G. N., Shabrova, E. V., Khamzina, E. I., Tarasov, A. V.
• Format: Article
• Language: English
• Subjects: Analytical Chemistry; Binding sites; Carbon fibers; Chemistry; Chemistry and Materials Science; Copper; Electrodes; Infrared analysis; Mass spectrometry; Oxidation; Reproducibility; Sensitivity analysis; Sensitizing; Sensors; Voltammetry
• ISSN: 1061-9348; 1608-3199
• DOI: 10.1134/S1061934824700229

A highly sensitive sensor based on carbon fiber paper modified with a shungite–copper formazanate composite is presented for the voltammetric determination of lidocaine. The synthesized organometallic complex, composite, and modified electrode are characterized by infrared spectroscopy, high-resolution mass spectrometry, elemental analysis, scanning electron microscopy, and cyclic and linear sweep voltammetry. The twofold increase in the current of the lidocaine oxidation peak on the modified electrode compared to the unmodified one is associated with the sensitizing effect of the composite modifier, which is due to an increase in the electroactive area and the number of lidocaine binding sites on the electrode surface. The sensor exhibits a wide dynamic range from 2 to 2120 µM with a low limit of detection of 0.18 µM lidocaine and high sensitivity of 0.755 µA/V µM. The interelectrode and intraelectrode repeatability of the analytical signal do not exceed 3.5%. The sensor response is stable within three weeks. The developed sensor was used for the determination of lidocaine in pharmaceuticals. The results of an analysis of real samples demonstrated good reproducibility (RSD ≤ 5.5%) and recovery (98–102%).