Synthesis of Transparent Bacterial Cellulose Films as a Platform for Targeted Drug Delivery in Wound Care

Bacterial cellulose (BC) can be chemically modified and combined with other materials to create composites with enhanced properties. In the medical field, biomaterials offer advantages, such as biocompatibility and sustainability, enabling improved therapeutic strategies and patient outcomes. Incorp...

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Bibliographic Details
Published in:Processes 2024-07, Vol.12 (7), p.1282
Main Authors: Amorim, Julia Didier Pedrosa de, Cavalcanti, Yasmim de Farias, Medeiros, Alexandre D’Lamare Maia de, Silva Junior, Cláudio José Galdino da, Durval, Italo José Batista, Costa, Andréa Fernanda de Santana, Sarubbo, Leonie Asfora
Format: Article
Language:English
Subjects:
Adsorption
Bacteria
Biocompatibility
Biofilms
Biomaterials
Biomedical materials
Black tea
Cell culture
Cellulose
Composite materials
Costs
Drug delivery
Gamma rays
Hydrogels
Lidocaine
Medical dressings
Medical materials
Pain management
Polymers
Sodium
Thermal stability
Wound healing
Wounds
γ Radiation
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Summary:Bacterial cellulose (BC) can be chemically modified and combined with other materials to create composites with enhanced properties. In the medical field, biomaterials offer advantages, such as biocompatibility and sustainability, enabling improved therapeutic strategies and patient outcomes. Incorporating lidocaine into wound dressings offers significant potential benefits. In this study, transparent BC films were produced in situ with an undefined minimal culture medium with a yeast and bacteria co-culture system on black tea (Camellia sinensis) and white sugar medium for three days. Lidocaine was incorporated ex situ into the BC matrix, and the composite film was sterilized using gamma radiation. Drug-release studies showed a two-stage release profile, with an initial fast release (24.6%) followed by a slower secondary release (27.2% cumulative release). The results confirmed the incorporation of lidocaine into the BC, producing highly transparent films with excellent thermal stability, essential for the storage and transportation of wound dressings. This study highlighted BC properties and drug incorporation and release behavior. The findings contribute towards optimizing wound dressings with controlled drug release, showcasing the potential of transparent BC films as an effective platform for wound care and drug-delivery applications.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr12071282