Comparison of [18F]FDG and [68 Ga]pentixafor PET/CT in Nasopharyngeal Carcinoma

Purpose This study aimed to explore the feasibility of [ 68  Ga]pentixafor positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma (NPC). Procedures This prospective study included patients with NPC who underwent [ 68  Ga]pentixafor PET/CT and 2-[ 18 F]fuo...

Full description

Saved in:
Bibliographic Details
Published in:Molecular imaging and biology 2024-08, Vol.26 (4), p.658-667
Main Authors: Liu, Mengna, Chen, Xi, Ding, Haoyuan, Shu, Qiaoqiao, Zheng, Yun, Chen, Yue, Cai, Liang
Format: Article
Language:English
Subjects:
Adult
Aged
Cancer
Cervical carcinoma
Computed tomography
Coordination Complexes - chemistry
CXCR4 protein
Feasibility studies
Female
Fluorine isotopes
Fluorodeoxyglucose F18 - chemistry
Glucose
Humans
Imaging
Lymph nodes
Lymphatic system
Male
Medicine
Medicine & Public Health
Metastases
Metastasis
Middle Aged
Nasopharyngeal carcinoma
Nasopharyngeal Carcinoma - diagnostic imaging
Nasopharyngeal Carcinoma - pathology
Nasopharyngeal Neoplasms - diagnostic imaging
Nasopharyngeal Neoplasms - pathology
Peptides, Cyclic - chemistry
Positron emission
Positron emission tomography
Positron Emission Tomography Computed Tomography - methods
Prospective Studies
Radiology
Research Article
Throat cancer
Tomography
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose This study aimed to explore the feasibility of [ 68  Ga]pentixafor positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma (NPC). Procedures This prospective study included patients with NPC who underwent [ 68  Ga]pentixafor PET/CT and 2-[ 18 F]fuoro-2-deoxy-D-glucose ([ 18 F]FDG) PET/CT within one week between November 2022 and March 2023. The [ 68  Ga]pentixafor and [ 18 F]FDG uptakes in primary and metastatic lesions were measured and compared. Results Twenty-five participants (21 patients for initial stage and four patients for recurrence detection) were enrolled in our study. The participants underwent [ 18 F]FDG PET/CT and [ 68  Ga]pentixafor PET/CT. [ 68  Ga]pentixafor PET/CT had the same detection rate as [ 18 F]FDG for primary tumor (96% vs. 96%). The [ 68  Ga]pentixafor maximum standard uptake value (SUV max ) and target-to-background ratio (TBR) of primary tumors were lower than those of [ 18 F]FDG (SUV max : 8.13 ± 2.78 vs. 14.25 ± 6.45; P  
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-024-01913-1