Electrochemical oxidative selective halogenation of pyrazolones for the synthesis of 4-halopyrazolones

An efficient and environmentally friendly electrochemical oxidative selective halogenation of pyrazolones has been developed under conditions free of metals, external oxidants, and external supporting electrolytes. The reaction demonstrates good functional group tolerance and maintains high efficien...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2024-07, Vol.22 (3), p.68-684
Main Authors: Li, Minghan, Yang, Shilin, Zhang, Jingyi, Gao, Zixun, Zheng, Linyu, Lu, Fangling, Feng, Yulin
Format: Article
Language:English
Subjects:
Chemical synthesis
Electrochemistry
Electrolytes
Functional groups
Halogenation
Metals
Oxidants
Oxidizing agents
Pyrazolones
Scale (corrosion)
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Summary:An efficient and environmentally friendly electrochemical oxidative selective halogenation of pyrazolones has been developed under conditions free of metals, external oxidants, and external supporting electrolytes. The reaction demonstrates good functional group tolerance and maintains high efficiency in large-scale synthesis, yielding moderate to excellent yields of the desired 4-halopyrazolones. This method provides a green and convenient route for the direct installation of a halogen moiety into bioactive pyrazolone derivatives, which can be utilized in a myriad of applications. An efficient and environmentally friendly electrochemical oxidative selective halogenation of pyrazolones has been developed under conditions free of metals, external oxidants, and external supporting electrolytes.
ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/d4ob00982g