ROLE OF VITAMIN E AND VITAMIN A ON THE SEVERITY OF ORAL MUCOSITIS CAUSED BY CHEMOTHERAPY. A RANDOMIZED DOUBLE-BLIND CROSS-OVER CLINICAL TRIAL

The study was conducted as a randomized, double-blind cross-over clinical trial study design. 20 eligible participants underwent two cross-over phases based on specific criteria. Furthermore, no significant variations were observed in mucositis severity and patients' pain response across differ...

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Bibliographic Details
Published in:International journal of medical dentistry 2024-04, Vol.28 (2), p.103-112
Main Authors: Gholami, Hossein, Mohamadifard, Mohamad Amir, Osmani, Freshteh, Alizadeh, Leili
Format: Article
Language:English
Subjects:
Cancer therapies
Chemotherapy
Clinical trials
Free radicals
Inflammation
Intervention
Mucositis
Pain
Radiation
Side effects
Software
Vitamin A
Vitamin E
Wound healing
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Summary:The study was conducted as a randomized, double-blind cross-over clinical trial study design. 20 eligible participants underwent two cross-over phases based on specific criteria. Furthermore, no significant variations were observed in mucositis severity and patients' pain response across different study days during the control and intervention phases (P > 0.05). Some have shown that these vitamins may be beneficial, while others have not found significant effects [21-23]. [...]this study aims to provide a more comprehensive understanding of the potential benefits of vitamins E and A to modulate oral mucositis and chemotherapy induced pain. 2. MATERIALS AND METHODS Study Design A randomized, double-blind, placebo controlled crossover clinical trial was conducted in the Iran Mehr hospital, affliated to the Birjand University of Medical Science, Birjand, Iran, from February 2022 to July 2022, to evaluate the effectiveness of vitamins E and A on the severity of oral mucositis caused by chemotherapy.
ISSN:2066-6063
2392-8018