Hodgkin's lymphoma and its association with EBV and HIV infection

Hodgkin's lymphoma (HL) constitutes a clonal expansion of what appears to be malignant B cells. Viruses are involved in its pathogenesis, such as the Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV). Since these viral infections have been shown to play key roles in the pathogenes...

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Bibliographic Details
Published in:Critical reviews in clinical laboratory sciences 2018-03, Vol.55 (2), p.102-114
Main Authors: Grewal, Ravnit, Irimie, Alexandra, Naidoo, Nasheen, Mohamed, Nooroudien, Petrushev, Bobe, Chetty, Manogari, Tomuleasa, Ciprian, Abayomi, Emmanuel-Akinola
Format: Article
Language:English
Subjects:
Adult
Epstein-Barr Virus Infections - complications
Female
HIV and EBV infections
HIV Infections - complications
Hodgkin Disease - complications
Hodgkin Disease - pathology
Hodgkin Disease - virology
Hodgkin's lymphoma
Humans
Lymph Nodes - pathology
Male
Middle Aged
pathology diagnosis
Young Adult
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Summary:Hodgkin's lymphoma (HL) constitutes a clonal expansion of what appears to be malignant B cells. Viruses are involved in its pathogenesis, such as the Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV). Since these viral infections have been shown to play key roles in the pathogenesis of HL, countries with a prevalence of HIV and EBV represent interesting population targets to study the pathogenesis of HL, linking the evolution of the disease with viral infections. Usually, patients present with late stage disease often involving the bone marrow at the time of diagnosis. The present paper discusses the role of viral infection in African countries, as HL is considered to be a malignant disease characterized by an inflammatory reaction to an aberrant B cell clone that is well known as the Reed-Sternberg cell (HRS).
ISSN:1040-8363
1549-781X
DOI:10.1080/10408363.2017.1422692