Rab proteins in fish and crustaceans: an overview

The Rab family of proteins is involved in organelle regulation, trafficking, signal transduction, mitosis, phagocytosis, growth differentiation, cytoskeleton protein depolymerization and other cellular functions and abnormal expression has been associated with many pathologies, including cancer. Pre...

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Bibliographic Details
Published in:Reviews in fish biology and fisheries 2024-09, Vol.34 (3), p.919-933
Main Authors: Zhu, Lei, Gu, Yanlong, Kong, Yiming, Wang, Xinru, Li, Hao, Hou, Libo, Kong, Xianghui
Format: Article
Language:English
Subjects:
Animals
Aquaculture
Aquaculture development
Aquatic animals
Aquatic crustaceans
Biomedical and Life Sciences
Crustacea
Crustaceans
Crystal structure
Cytoplasmic organelles
Cytoskeleton
Depolymerization
family
Fish
Fisheries
Freshwater & Marine Ecology
Genes
immune response
Immune system
Life Sciences
Localization
Mitosis
Pathogens
Phagocytosis
Proteins
Rab protein
Reviews
Shellfish
Signal transduction
Yeast
Zebrafish
Zoology
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Summary:The Rab family of proteins is involved in organelle regulation, trafficking, signal transduction, mitosis, phagocytosis, growth differentiation, cytoskeleton protein depolymerization and other cellular functions and abnormal expression has been associated with many pathologies, including cancer. Previous work has focused on Rab function in higher animals but fish, crustaceans and other aquatic animals also express the Rab proteins. The current review summarizes research progress on Rab proteins, focusing on immune defense against pathogens in aquatic animals. Some differences in Rab protein function between aquatic and higher animals were found and greater involvement in the fish and crustacean immune system than that of higher animals. Novel insights into Rab protein in aquatic animals are offered with implications for the development of aquaculture strategies.
ISSN:0960-3166
1573-5184
DOI:10.1007/s11160-024-09859-x