Tear‐borne interleukin 1‐beta and transforming growth factor‐beta and its relationship with clinical parameters in neophytes contact lens wearers

Aims/Purpose: To determine the presence of Interleukin 1‐beta (IL1‐β) and Transforming growth factor‐beta (TGF‐β) in the tears of neophytes contact lens wearers; and investigate the relationship between their concentration, tear stability, and ocular physiology findings. Methods: In this clinical tr...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2024-01, Vol.102 (S279), p.n/a
Main Authors: Pereira, Eduardo Insua, Lira, Madalena, Sampaio, Ana Paula
Format: Article
Language:English
Subjects:
Contact lenses
Cytokines
Growth factors
Homeostasis
Hyperemia
Interleukin 1
Tears
Transforming growth factor-b
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Summary:Aims/Purpose: To determine the presence of Interleukin 1‐beta (IL1‐β) and Transforming growth factor‐beta (TGF‐β) in the tears of neophytes contact lens wearers; and investigate the relationship between their concentration, tear stability, and ocular physiology findings. Methods: In this clinical trial, 12 neophytes (5 males, 24.0 ± 5.0 years) were dispensed with delefilcon A contact lenses. Physiological responses (bulbar and limbal hyperemia), non‐invasive tear break‐up times, and tear sample collections were obtained in the morning (before lens insertion; 9–10 a.m.) and afternoon (before lens removal; 7–8 p.m.) of the same day. The tear samples were assayed for IL1‐β and TGF‐β concentrations using Enzyme‐Linked Immunoabsorbent Assay kits. A parallel control group of 11 individuals (6 males, 25.0 ± 5.0) was also assessed to determine the levels of the biomarkers in the tears of non‐contact lens wearers. Results: Patients wore lenses for an average of 7:20 [6,9] h. Bulbar and limbal hyperemia increased throughout the day (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.16242