Recent advances in stimuli‐responsive theranostic systems with aggregation‐induced emission characteristics

Theranostic systems by integrating the tumor imaging and tumor therapeutic capabilities into one platform have attracted numerous attentions from worldwide researchers. Despite the great developments, their clinical application is still in the nascent stage, owing to the unsatisfied imaging quality...

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Bibliographic Details
Published in:Aggregate (Hoboken) 2021-02, Vol.2 (1), p.48-65
Main Authors: Hu, Jing‐Jing, Jiang, Wenlian, Yuan, Lizhen, Duan, Chong, Yuan, Qiming, Long, Zi, Lou, Xiaoding, Xia, Fan
Format: Article
Language:English
Subjects:
Acids
aggregation induced emission
Chemotherapy
Design
Drug delivery systems
Efficiency
Enzymes
imaging
Medical diagnosis
Nanoparticles
Peptides
Quantum dots
stimuli‐responsive
theranostics
tumor therapy
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Summary:Theranostic systems by integrating the tumor imaging and tumor therapeutic capabilities into one platform have attracted numerous attentions from worldwide researchers. Despite the great developments, their clinical application is still in the nascent stage, owing to the unsatisfied imaging quality and limited therapeutic efficacy. Fortunately, the emerging of aggregation‐induced emission (AIE) molecules with unique fluorescence property offers an opportunity to solve the imaging problem. Besides, further utilizing the tumor microenvironments and external triggers to design the stimuli‐responsive imaging‐guided therapy could enhance the therapeutic efficacy and reduce the side effects. In this review, the advancements in stimuli‐responsive theranostic systems with AIE characteristics are summarized. Theranostic systems are first classified according to their treatment modes, and then subdivided based on various stimuli, including pH, redox, enzyme, and light. In each section, the design strategies and application examples are introduced. At last, the current state of the art, limitations, as well as prospects are also discussed. The advancements in the construction of stimuli‐triggered theranostic systems that can achieve simultaneous precise imaging and efficient therapy are summarized. Theranostic systems are introduced based on the different therapy modes, types of responses, design strategy of systems, and application fields. At last, the current state of the art, limitations, as well as prospects are also discussed.
ISSN:2692-4560
2766-8541
2692-4560
DOI:10.1002/agt2.10