Analysis of Risk Factors of Cartilage Wear in Lateral Compartment of Patients with Varus Knee Osteoarthritis

The objective of this study was to investigate the risk factors of cartilage wear in the lateral compartment of patients with varus knee osteoarthritis (VKO). The sample consisted of 110 patients with VKO who underwent total knee arthroplasty at Fujian hospital. The patients were divided into the la...

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Published in:Pakistan journal of zoology 2024-08, Vol.56 (4), p.1903
Main Author: Li, Ying
Format: Article
Language:English
Subjects:
Abrasion
Anterior cruciate ligament
Arthritis
Arthroplasty (knee)
Body mass index
Care and treatment
Cartilage
Cartilage diseases
Clinical significance
Cytokines
Disease
IL-1β
Interleukin 6
Joint replacement surgery
Knee
Knee joint
Labor
Ligaments
Menisci
Meniscus
Middle age
Older people
Osteoarthritis
Patients
Physiological aspects
Quality of life
Range of motion
Risk analysis
Risk factors
Synovial fluid
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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description The objective of this study was to investigate the risk factors of cartilage wear in the lateral compartment of patients with varus knee osteoarthritis (VKO). The sample consisted of 110 patients with VKO who underwent total knee arthroplasty at Fujian hospital. The patients were divided into the lateral compartment cartilage abrasion group (n=30) and the lateral compartment cartilage non abrasion group (n=80) according to the lateral compartment cartilage status. The clinical data and laboratory indexes of patients were collected, and the risk factors of cartilage wear in lateral compartment of patients with VKO were analyzed by single factor and multi factor logistic regression. Labor intensity, imaging grade, integrity of lateral meniscus and anterior cruciate ligament, and course of disease may be the risk factors for cartilage wear of lateral compartment in patients with VKO (P
doi_str_mv 10.17582/journal.pjz/20221124151150
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The sample consisted of 110 patients with VKO who underwent total knee arthroplasty at Fujian hospital. The patients were divided into the lateral compartment cartilage abrasion group (n=30) and the lateral compartment cartilage non abrasion group (n=80) according to the lateral compartment cartilage status. The clinical data and laboratory indexes of patients were collected, and the risk factors of cartilage wear in lateral compartment of patients with VKO were analyzed by single factor and multi factor logistic regression. Labor intensity, imaging grade, integrity of lateral meniscus and anterior cruciate ligament, and course of disease may be the risk factors for cartilage wear of lateral compartment in patients with VKO (P&lt;0.05). The levels of IL-6, TNF-α and IL-1β in the joint fluid of the cartilage wear group were significantly higher than those of the non-wear group (P&lt;0.05). The results showed that the heavy labor intensity, the absence or insufficiency of the lateral meniscus, the absence or insufficiency of the anterior cruciate ligament, the long course of disease, and the high level of IL-6, TNF-α and IL-1β was an independent risk factor for cartilage wear of lateral compartment in patients with VKO (P&lt;0.05). It was concluded that heavy labor intensity, absence or incompleteness of lateral meniscus, absence or incompleteness of anterior cruciate ligament, long course of disease and high level of IL-6 and TNF-α in synovial fluid IL-1β Level is an independent risk factor for cartilage wear of lateral compartment in patients with VKO.</description><identifier>ISSN: 0030-9923</identifier><identifier>DOI: 10.17582/journal.pjz/20221124151150</identifier><language>eng</language><publisher>Lahore: Knowledge Bylanes</publisher><subject>Abrasion ; Anterior cruciate ligament ; Arthritis ; Arthroplasty (knee) ; Body mass index ; Care and treatment ; Cartilage ; Cartilage diseases ; Clinical significance ; Cytokines ; Disease ; IL-1β ; Interleukin 6 ; Joint replacement surgery ; Knee ; Knee joint ; Labor ; Ligaments ; Menisci ; Meniscus ; Middle age ; Older people ; Osteoarthritis ; Patients ; Physiological aspects ; Quality of life ; Range of motion ; Risk analysis ; Risk factors ; Synovial fluid ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Pakistan journal of zoology, 2024-08, Vol.56 (4), p.1903</ispartof><rights>COPYRIGHT 2024 Knowledge Bylanes</rights><rights>(c)2024 Pakistan Journal of Zoology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Li, Ying</creatorcontrib><title>Analysis of Risk Factors of Cartilage Wear in Lateral Compartment of Patients with Varus Knee Osteoarthritis</title><title>Pakistan journal of zoology</title><description>The objective of this study was to investigate the risk factors of cartilage wear in the lateral compartment of patients with varus knee osteoarthritis (VKO). The sample consisted of 110 patients with VKO who underwent total knee arthroplasty at Fujian hospital. The patients were divided into the lateral compartment cartilage abrasion group (n=30) and the lateral compartment cartilage non abrasion group (n=80) according to the lateral compartment cartilage status. The clinical data and laboratory indexes of patients were collected, and the risk factors of cartilage wear in lateral compartment of patients with VKO were analyzed by single factor and multi factor logistic regression. Labor intensity, imaging grade, integrity of lateral meniscus and anterior cruciate ligament, and course of disease may be the risk factors for cartilage wear of lateral compartment in patients with VKO (P&lt;0.05). The levels of IL-6, TNF-α and IL-1β in the joint fluid of the cartilage wear group were significantly higher than those of the non-wear group (P&lt;0.05). The results showed that the heavy labor intensity, the absence or insufficiency of the lateral meniscus, the absence or insufficiency of the anterior cruciate ligament, the long course of disease, and the high level of IL-6, TNF-α and IL-1β was an independent risk factor for cartilage wear of lateral compartment in patients with VKO (P&lt;0.05). It was concluded that heavy labor intensity, absence or incompleteness of lateral meniscus, absence or incompleteness of anterior cruciate ligament, long course of disease and high level of IL-6 and TNF-α in synovial fluid IL-1β Level is an independent risk factor for cartilage wear of lateral compartment in patients with VKO.</description><subject>Abrasion</subject><subject>Anterior cruciate ligament</subject><subject>Arthritis</subject><subject>Arthroplasty (knee)</subject><subject>Body mass index</subject><subject>Care and treatment</subject><subject>Cartilage</subject><subject>Cartilage diseases</subject><subject>Clinical significance</subject><subject>Cytokines</subject><subject>Disease</subject><subject>IL-1β</subject><subject>Interleukin 6</subject><subject>Joint replacement surgery</subject><subject>Knee</subject><subject>Knee joint</subject><subject>Labor</subject><subject>Ligaments</subject><subject>Menisci</subject><subject>Meniscus</subject><subject>Middle age</subject><subject>Older people</subject><subject>Osteoarthritis</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Quality of life</subject><subject>Range of motion</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Synovial fluid</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>0030-9923</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNptkctKAzEUhmehoNS-Q8B121wmMwmuSrEqFhTxsgyZzJk2dWZSkxSpT2_UChbMWeRcvv8Q8mfZOcFjUnJBJ2u39b1ux5v1x4RiSgmhOeGEcHyUnWLM8EhKyk6yYQhrnE5ecErFadZOk2oXbECuQQ82vKK5NtH573qmfbStXgJ6Ae2R7dFCR_C6RTPXbdKwgz5-gfc62pQG9G7jCj1rvw3otgdAdyGCS-DK22jDWXbc6DbAcH8Psqf55ePserS4u7qZTRcjQwWPo0qSkvISV5zzRsqqFIIVBWkqYLzSpCigBs1qqKiRrJJgZF7WopGkNljqvGSD7Pxn78a7ty2EqPbfExTDQgrBy7_UUregbN-46LXpbDBqKjCTOc5zkqjxP1SKGjprXA-NTf0DwcWPwHgXgodGbbzttN8pgtW3Wb-vUcksdWgW-wR4tYze</recordid><startdate>20240831</startdate><enddate>20240831</enddate><creator>Li, Ying</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7SS</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20240831</creationdate><title>Analysis of Risk Factors of Cartilage Wear in Lateral Compartment of Patients with Varus Knee Osteoarthritis</title><author>Li, Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-b9172570b555f99b7883661fbe35ba166edea3deb2c93b9ec947d8f91dc09a473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abrasion</topic><topic>Anterior cruciate ligament</topic><topic>Arthritis</topic><topic>Arthroplasty (knee)</topic><topic>Body mass index</topic><topic>Care and treatment</topic><topic>Cartilage</topic><topic>Cartilage diseases</topic><topic>Clinical significance</topic><topic>Cytokines</topic><topic>Disease</topic><topic>IL-1β</topic><topic>Interleukin 6</topic><topic>Joint replacement surgery</topic><topic>Knee</topic><topic>Knee joint</topic><topic>Labor</topic><topic>Ligaments</topic><topic>Menisci</topic><topic>Meniscus</topic><topic>Middle age</topic><topic>Older people</topic><topic>Osteoarthritis</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Quality of life</topic><topic>Range of motion</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Synovial fluid</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ying</creatorcontrib><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural &amp; 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The sample consisted of 110 patients with VKO who underwent total knee arthroplasty at Fujian hospital. The patients were divided into the lateral compartment cartilage abrasion group (n=30) and the lateral compartment cartilage non abrasion group (n=80) according to the lateral compartment cartilage status. The clinical data and laboratory indexes of patients were collected, and the risk factors of cartilage wear in lateral compartment of patients with VKO were analyzed by single factor and multi factor logistic regression. Labor intensity, imaging grade, integrity of lateral meniscus and anterior cruciate ligament, and course of disease may be the risk factors for cartilage wear of lateral compartment in patients with VKO (P&lt;0.05). The levels of IL-6, TNF-α and IL-1β in the joint fluid of the cartilage wear group were significantly higher than those of the non-wear group (P&lt;0.05). The results showed that the heavy labor intensity, the absence or insufficiency of the lateral meniscus, the absence or insufficiency of the anterior cruciate ligament, the long course of disease, and the high level of IL-6, TNF-α and IL-1β was an independent risk factor for cartilage wear of lateral compartment in patients with VKO (P&lt;0.05). It was concluded that heavy labor intensity, absence or incompleteness of lateral meniscus, absence or incompleteness of anterior cruciate ligament, long course of disease and high level of IL-6 and TNF-α in synovial fluid IL-1β Level is an independent risk factor for cartilage wear of lateral compartment in patients with VKO.</abstract><cop>Lahore</cop><pub>Knowledge Bylanes</pub><doi>10.17582/journal.pjz/20221124151150</doi><oa>free_for_read</oa></addata></record>
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ispartof Pakistan journal of zoology, 2024-08, Vol.56 (4), p.1903
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language eng
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source Nexis UK
subjects Abrasion
Anterior cruciate ligament
Arthritis
Arthroplasty (knee)
Body mass index
Care and treatment
Cartilage
Cartilage diseases
Clinical significance
Cytokines
Disease
IL-1β
Interleukin 6
Joint replacement surgery
Knee
Knee joint
Labor
Ligaments
Menisci
Meniscus
Middle age
Older people
Osteoarthritis
Patients
Physiological aspects
Quality of life
Range of motion
Risk analysis
Risk factors
Synovial fluid
Tumor necrosis factor-TNF
Tumor necrosis factor-α
title Analysis of Risk Factors of Cartilage Wear in Lateral Compartment of Patients with Varus Knee Osteoarthritis
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