A Comparative Study Between Pharmacological Efficacy of Meperidine and Oxycodone for Preventing Shivering in Patients who underwent Inguinal Hernia Repair with Spinal Anesthesia

• Published in: Pakistan journal of zoology 2024-08, Vol.56 (4), p.1693
• Main Authors: Akbari, Ghodrat Akhavan, Hayadokht, Saman, Ahari, Saeed Sadeghiyeh, Gasi, Ahmad
• Format: Article
• Language: English
• Subjects: Anesthesia; Blood pressure; Cardiovascular system; Chi-square test; Clinical trials; Comparative analysis; Comparative studies; Diabetes; Effectiveness; Heart rate; Hernia; Hernias; Meperidine; Nausea; Oxycodone; Patients; Physiological aspects; Placebos; Recovery time; Shivering; Surgery; Vomiting
• ISSN: 0030-9923
• DOI: 10.17582/journal.pjz/20221116221130

Postoperative shivering control without lengthening recovery time and worsening cardiovascular system is important and necessary. The main objective of the present study was to evaluate the efficiency of Meperidine and Oxycodone in preventing shivering in patients who underwent inguinal hernia repair with spinal anesthesia. The present study consisted of patients with herniorrhaphy in the Fatemi and Imam Hospital of Ardabil who were studied through a double-blind clinical trial. with spinal anesthesia from 2017 through 18. In the study110 cases with hernia were included. In both studied groups of Meperidine or oxycodone, patients were allocated randomly. Interventions began half an hour before spinal anesthesia in the operating room. Each groups had their own structured treatment plan so that the first and the second groups received 5 mg of oxycodone and placebo respectively. After the patients being stable, Meperidine 0.4 mg/kg (2 CC) was injected to the second group following the spinal anesthesia. Normal saline (2CC) injected to the first group as placebo. Patients were evaluated for shivering, nausea, vomiting and other complications up to 4 hours after surgery. After the operation, an uninformed questioner asked for shivering, nausea and vomiting and other complications of the operation, including dizziness and headache, for up to 4 hours (at intervals of 0, 2 and 4 hours), filling the relevant questionnaire and then the data were entered into SPSSv 21 and analyzed using Chi Square, T test and Fisher exact tests. A significance Level of 0.05 was considered for all the tests. The incidence of shivering in the oxycodone group at zero time (in recovery room) was significantly lower than the Meperidine group. But in other times, oxycodone had no significant effect on shivering compared to Meperidine. In both studied groups, there was not significant differences between rate of nausea and vomiting. We showed that oxycodone pills immediately after surgery may reduce the incidence of shivering significantly and also effective in shivering control as much as Meperidine at the other times of recovery.