Cytotoxicity and Compatibility of Polymeric Blend: Evaluation of the Cytotoxicity in Fibroblast Bovine Cells and Compatibility of Poly(ɛ-Caprolactone)/Poly(Methyl Methacrylate-co-Butyl Methacrylate) Blend Films

• Published in: Polymer-plastics technology and engineering 2017-07, Vol.56 (10), p.1076-1083
• Main Authors: Souza, Nelson Luis G. D., Munk, Michele, Brandão, Humberto M., de Oliveira, Luiz Fernando C.
• Format: Article
• Language: English
• Subjects: Biocompatibility; Carbonyl groups; Carbonyls; Cattle; Compatibility; cytotoxicity; Dichloromethane; Fibroblasts; Fourier transforms; Infrared analysis; Infrared spectroscopy; poly(methyl methacrylate-co-butyl methacrylate); poly(ϵ-caprolactone); Polycaprolactone; Polymer blends; Polymethyl methacrylate; Raman spectroscopy; Solution blending; Thermogravimetric analysis; Toxicity
• ISSN: 0360-2559; 1525-6111
• DOI: 10.1080/03602559.2016.1253735

Blends between poly(ϵ-caprolactone) and poly(methyl methacrylate-co-butyl methacrylate) were prepared by solution blending in the presence of dichloromethane as solvent. The compatibility of the blends was studied by Fourier-transform infrared spectroscopy, Raman spectroscopy, micro-Raman imaging, and thermogravimetric analysis. Cytotoxicity assays were also performed to assess the feasibility of using such materials in veterinary devices. Based on results, we conclude that poly(ϵ-caprolactone) and poly(methyl methacrylate-co-butyl methacrylate)-form compatible blends owing to specific interactions between carbonyl groups of poly(methyl methacrylate-co-butyl methacrylate) and hydrogens present in the polymeric chain of poly(ϵ-caprolactone). Furthermore, these materials were not toxic to bovine fibroblasts, which supports their possible use in cattle veterinary devices.