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The prognostic significance of glucose transporter-1 protein in malignant pleural mesothelioma
[LANGUAGE= "English"] INTRODUCTION: Malignant pleural mesothelioma (MPM) is a rare condition with a poor survival rate. This study was designed to determine the prognostic importance of glucose transporter-1 (GLUT-1) expression in operated patients with pleural mesothelioma.METHODS: Patien...
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Published in: | Haydarpașa Numune Hastanesi tıp dergisi = The medical journal of Haydarpașa Numune Hospital 2023-12, Vol.63 (4), p.531 |
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Main Author: | |
Format: | Article |
Language: | English |
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Online Access: | Get full text |
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Summary: | [LANGUAGE= "English"] INTRODUCTION: Malignant pleural mesothelioma (MPM) is a rare condition with a poor survival rate. This study was designed to determine the prognostic importance of glucose transporter-1 (GLUT-1) expression in operated patients with pleural mesothelioma.METHODS: Patients operated with a diagnosis of pleural mesothelioma between January 2005 and September 2014 were retrospectively analyzed in terms of age, gender, diagnosis method, maximum standardized uptake value in positron emission tomography, operation, pathology, GLUT-1 expression in the specimen, morbidity, and mortality.RESULTS: One hundred and twenty-nine patients were diagnosed as MPM. 75 (54 male and 21 female) of these patients underwent therapeutic operations. The mean age was 63 (range 41–89). Extrapleural pneumonectomy was performed in 27, pleurectomy/decortication in 25, and radical pleurectomy in 23 patients. The pathological diagnosis was epithelial in 67 and biphasic in 8 patients. All the patients were referred for adjuvant chemoradiotherapy and 69% completed the intended trimodality treatment. In 61 (81.3%) of the operated patients, the parietal pleura material was positive for GLUT-1. The morbidity was seen in 16 of the operated patients. The average survival time was 23.7 months after surgery. The average survival time was 24.5 months in patients with GLUT-1 expression |
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ISSN: | 1300-6363 |
DOI: | 10.14744/hnhj.2022.43765 |