Brain changes underlying a psychedelic state

The greatest effect was in the default mode network, which is thought to generate a person's sense of self, space and time (Fig. lb). [...]across all sessions, whole-brain changes in neural communication correlated with the intensity of the subjective psychedelic experience (Fig. 1c). Siegel et...

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Bibliographic Details
Published in:Nature (London) 2024-08, Vol.632 (8023), p.32-33
Main Author: Petridis, Petros D
Format: Article
Language:English
Subjects:
Brain
Clinical trials
Communication
Ecstasy
Population studies
Psilocybin
Psychedelic drugs
Synchronization
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Summary:The greatest effect was in the default mode network, which is thought to generate a person's sense of self, space and time (Fig. lb). [...]across all sessions, whole-brain changes in neural communication correlated with the intensity of the subjective psychedelic experience (Fig. 1c). Siegel etai, provide compelling evidence that desynchronized brain activity underlies the acute psychedelic state and might contribute to persistent changes in neural activity in brain regions that are responsible for controlling a person's sense of self, emotions and life-narrative. Ultimately, however, large clinical trials with diverse patient populations and factorial study designs (which enable more than one intervention to be evaluated simultaneously) will be needed to examine the efficacy of psychedelics such as psilocybin and the role of talk therapy in treatment.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-024-02154-6