Metasurface Platform Incorporating Aggregation Induced Emission Based Biosensor for Enhanced Human Serum Albumin Detection

Metasurfaces exhibit excellent optical performance to enhance the light–matter interaction of target molecules in biosensing based on its well‐optimized nanostructured unit cells. In the meantime, fluorescence (FL) biosensors with aggregation induced emissions (AIE) features also demonstrate outstan...

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Bibliographic Details
Published in:Advanced optical materials 2024-08, Vol.12 (23), p.n/a
Main Authors: Hu, Qi, Iwanaga, Masanobu, Tang, Youhong
Format: Article
Language:English
Subjects:
AIE FL biosensors
Background noise
Biomarkers
Biosensors
Complex variables
HSA detection
Human performance
metasurface platform
Metasurfaces
multi‐level immobilizations
Proteins
Serum albumin
Silicon
Si‐nanocolumns
Target detection
Urine
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Summary:Metasurfaces exhibit excellent optical performance to enhance the light–matter interaction of target molecules in biosensing based on its well‐optimized nanostructured unit cells. In the meantime, fluorescence (FL) biosensors with aggregation induced emissions (AIE) features also demonstrate outstanding performance in biomarker detection due to their fast response, high selectivity, and low background noise. Nevertheless, extremely low‐level analytes are difficult to detect in practical applications since complex urine samples include a number of uncontrolled variables such as impurities, autofluorescence, other urine components, etc. At present, improving optical signal sensitivity of human serum albumin (HSA) detection is always a big challenge to overcome such interference in human urine scenarios. In this work, first an AIE‐based FL biosensor TPE‐4TA is combined with an all‐dielectric metasurface platform to achieve quantitative detection of trace HSA in urine by utilizing biofunctionalization protocols on the silicon (Si) nanostructures. The results indicate significant FL enhancement in the metasurface platform that offers a promising pathway for improving biomarker detection in the future. This research first combined an AIE‐based FL biosensor TPE‐4TA with an all‐dielectric metasurface platform to achieve quantitative detection of trace HSA in urine by utilizing biofunctionalization protocols on the silicon nanostructures. The results demonstrate significant FL enhancement in the metasurface platform that offers a promising pathway for improving biomarker detection in the future.
ISSN:2195-1071
2195-1071
DOI:10.1002/adom.202400868