Assessment of Virulence Potential and Antibiotic Resistance Profiles in E. coli Isolates from Selected Ground Water Samples Around the Control Open Dump Sites in Sri Lanka

   Urbanization and accelerated industrialization have led to significant waste generation following the accumulation of massive amounts of solid waste in open dump sites. Groundwater contamination is one of the critical ecological concerns associated with the percolation of leachate from dump sites...

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Bibliographic Details
Published in:Waste and biomass valorization 2024, Vol.15 (9), p.5475-5485
Main Authors: Liyanage, G. Y., Wijerathna, P. A. K. C., Bandara, S. M. T. V., Manage, Pathmalal M.
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antibiotics
Bioaccumulation
Colitis
Contamination
Drug resistance
E coli
Engineering
Environment
Environmental Engineering/Biotechnology
Groundwater pollution
Hemolytic uremic syndrome
Industrial Pollution Prevention
Intimin
Leachates
Original Paper
Percolation
Renewable and Green Energy
Shiga toxin
Soil contamination
Solid wastes
Thrombocytopenic purpura
Thrombotic thrombocytopenic purpura
Toxins
Urbanization
Virulence
Waste Management/Waste Technology
Water analysis
Water sampling
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Summary:   Urbanization and accelerated industrialization have led to significant waste generation following the accumulation of massive amounts of solid waste in open dump sites. Groundwater contamination is one of the critical ecological concerns associated with the percolation of leachate from dump sites. E.coli O157 is a particular virulent serotype which produces Intimin and Shiga toxins, that cause severe diseases including Hemorrhagic Colitis, Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura in humans. The focus of the present study is to study the virulence potential and antibiotic resistance profiles in E. coli isolates from selected Karadiyana, Methotamulla and Kerawalapitiya control open dump sites in Sri Lanka. The E.coli was isolated following the standard MPN method and 5 randomly selected ( n = 5) colonies from each location were subjected to the virulence potential tests and antibiotic resistivity study. The results showed the total coliform count was ranged from 0–120 MPN/mL around the Kardiyana dump site whereas 0–75 MPN/mL and 3–115 MPN/mL recorded in the Methotamulla and the Kerawalapitiya dump sites. Overall, resistance in isolated E.coli against AMX, AMP, SUF/ TRI, SDI, CLOX, TET and ERM was high (> 70%) compared with the other tested antibiotics namely CIP, GEN and AZY (
ISSN:1877-2641
1877-265X
DOI:10.1007/s12649-024-02544-x