Dexamethasone-Induced Modifications of the Intracerebral Hemorrhage-Related Reactions of Astrocytes in Rats

In rats with experimental intracerebral hemorrhage, we studied reactions of astrocytes, their involvement in the formation of the glial scar, and modifications of the above reactions induced by the introduction of large doses of dexamethasone. The dependence of the state of the glial scar on the siz...

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Bibliographic Details
Published in:Neurophysiology (New York) 2022-05, Vol.54 (3-4), p.126-135
Main Authors: Savosko, S. I., Kuraieva, A. V., Chaikovsky, Yu. B., Grabovoy, A. N., Makarenko, O. M.
Format: Article
Language:English
Subjects:
Astrocytes
Biomedical and Life Sciences
Biomedicine
Central nervous system depressants
Dexamethasone
Glial fibrillary acidic protein
Gliosis
Hemorrhage
Inflammation
Intracerebral hemorrhage
Mediation
Neurophysiology
Neurosciences
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Summary:In rats with experimental intracerebral hemorrhage, we studied reactions of astrocytes, their involvement in the formation of the glial scar, and modifications of the above reactions induced by the introduction of large doses of dexamethasone. The dependence of the state of the glial scar on the size of the hemorrhage and the severity of the inflammation was observed. Dexamethasone introduction led to a sharp increase in the expression of GFAP and an increase in the specific density of astrocytes around the hemorrhage zone. The dynamics of astrogliosis under such conditions no longer depended on morphological parameters of the hemorrhage in the brain. Despite new data on the effect of dexamethasone on the reactive astrogliosis in the model of intracerebral hemorrhage, the question of changes in the morphological type of the scar within the perihematomal area (glial scar or membrane) requires further research.
ISSN:0090-2977
1573-9007
DOI:10.1007/s11062-024-09944-8