Evaluation of dermal and ocular safety of natural products based on Murraya paniculata, Eucalyptus sp. and Indigofera suffruticosa Mill. in New Zealand rabbits

This study was conducted to evaluate the acute dermal and ocular irritant potential of three natural products obtained from medicinal plants Murraya paniculata (PNI), Eucalyptus sp. (PNII), and Indigofera suffruticosa Mill. (PNIII) for topical use in veterinary medicine. For the assessment of acute...

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Bibliographic Details
Published in:Revista de medicina veterinaria y de zootecnia 2024-05, Vol.71 (2)
Main Authors: Rodríguez-Leblanch, E, Gonzáles-Pérez, Y, Duverger-González, Y, Mora-Tassé, Y, Fong-Lores, O, Suárez-Arias, P A, Pérez-Paredes, L, Salas-Martínez, H
Format: Article
Language:English
Subjects:
Classification
Corrosion products
Eucalyptus
Evaluation
Herbal medicine
Indigofera suffruticosa
Irritation
Medicinal plants
Murraya paniculata
Natural products
Rabbits
Signs and symptoms
Skin
Veterinary medicine
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Summary:This study was conducted to evaluate the acute dermal and ocular irritant potential of three natural products obtained from medicinal plants Murraya paniculata (PNI), Eucalyptus sp. (PNII), and Indigofera suffruticosa Mill. (PNIII) for topical use in veterinary medicine. For the assessment of acute dermal and ocular irritability, methodologies from the Organization for Economic Cooperation and Development (OECD) were employed through guidelines 404 and 405, respectively, using New Zealand albino rabbits. The evaluated products showed no signs or symptoms of irritation/corrosion on the skin and eyes, exhibiting dermal and ocular irritation indices within the range of classification of non-irritating substances, according to the OECD Harmonized Integrated Classification System.
ISSN:0120-2952
2357-3813
DOI:10.15446/rfmvz.v71n2.111493