Assessment of the circulating soluble endothelial cell adhesion molecules and pentraxin 3 levels in predicting preterm delivery within 72 h

• Published in: International Journal of Medical Biochemistry 2023-01, Vol.6 (1), p.1
• Main Authors: Davutoglu, Ebru Alici, Firat, Asuman Akkaya, Ozel, Aysegul, Madazli, Riza
• Format: Article
• Language: English
• Subjects: Analysis; Biomarkers; Cell adhesion & migration; Cervix; Endothelium; Enzyme-linked immunosorbent assay; Gestational age; Health aspects; Hospitalization; Infants (Premature); Logistics services; Pregnancy; Pregnant women; Premature birth; Women
• ISSN: 2587-2362; 2618-642X
• DOI: 10.14744/ijmb.2022.55477

[LANGUAGE= "English"] INTRODUCTION: The study aimed to evaluate maternal serum soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), and PTX-3 concentrations in patients with threatened preterm labor (TPL) and to predict preterm delivery within 72 h after hospitalization. Premature birth is defined as the risk of the newborn being in labor before the 37th week of pregnancy is completed. Preterm birth affects 9–13% of whole pregnancies. The major causes of neonatal morbidity and mortality.METHODS: This study consisted of 54 women with TPL and 31 healthy pregnant women. The TPL group was further divided into two subgroups; patients who gave birth within 72 h after the hospitalization was applied to as a preterm delivery group and who gave birth at ≥37 weeks were referred to as the term delivery group. Maternal serum levels of sICAM-1, sVCAM-1, sE-selectin, and PTX-3 were measured with the use of ELISA kits.RESULTS: Maternal serum sICAM-1 and PTX-3 levels were significantly higher in a preterm delivery group compared with the other two groups (preterm vs. control and preterm vs. term p