The relationship between ischemia-modified albumin/albumin ratio levels and disease severity in COVID-19 patients

[LANGUAGE= "English"] INTRODUCTION: In COVID-19 infection, oxidative stress occurs with the abnormal release of proinflammatory cytokines and the disruption of the balance between oxidants and antioxidants. In our study, we aimed to investigate the relationship between ischemia-modified al...

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Bibliographic Details
Published in:International Journal of Medical Biochemistry 2023, Vol.6 (3), p.143-149
Main Author: aksit, murat
Format: Article
Language:English
Subjects:
Albumin
Antioxidants
Biomarkers
Cobalt
COVID-19
Cytokines
Health aspects
Hospital patients
Hospitalization
Infection
Ischemia
Medical research
Medicine, Experimental
Multivariate analysis
Oxidative stress
Risk factors
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Summary:[LANGUAGE= "English"] INTRODUCTION: In COVID-19 infection, oxidative stress occurs with the abnormal release of proinflammatory cytokines and the disruption of the balance between oxidants and antioxidants. In our study, we aimed to investigate the relationship between ischemia-modified albumin (IMA), a biomarker of oxidative stress, and the severity of the disease in hospitalized COVID-19 patients.METHODS: One hundred and twenty-four hospitalized patients with a diagnosis of COVID-19 were included in the study. These patients were divided into critical and non-critical groups. Serum IMA levels were measured by the colorimetric albumin cobalt-binding method. The IMA-albumin ratio (IMAR) was calculated by dividing IMA values by albumin values.RESULTS: The IMA and IMAR values of the critical COVID-19 group were statistically significantly higher than the non-critical group. In the multivariate analysis, the two variables IMAR and glucose were found to have the most important role in the severity of COVID-19 disease. For IMAR, the area under the ROC curve had a value of 0.725 (95% confidence interval 0.636–0.803).DISCUSSION AND CONCLUSION: IMA and IMAR levels of the critical group were found to be higher than the non-critical group in COVID patients. We have observed that IMAR levels are associated with the severity of the disease and that IMAR is an independent prognostic risk factor for the disease.
ISSN:2587-2362
2618-642X
DOI:10.14744/ijmb.2023.74436