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The effect of hormone therapy on physiological uptake of the endometrium on [18F]F-FDG PET in postmenopausal women
Objective The effects of hormonal therapy, estrogen-based hormone replacement therapy (HRT), and anti-tumor hormone therapy, such as tamoxifen, on the physiological uptake of the endometrium on 2-deoxy-2[ 18 F]fluoro- d -glucose ([ 18 F]F-FDG) positron emission tomography (PET) in postmenopausal wom...
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| Published in: | Annals of nuclear medicine 2024-09, Vol.38 (9), p.726-733 |
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| container_title | Annals of nuclear medicine |
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| creator | Nakamoto, Ryusuke Yakami, Masahiro Nobashi, Tomomi W. Isoda, Hiroyoshi Nakamoto, Yuji |
| description | Objective
The effects of hormonal therapy, estrogen-based hormone replacement therapy (HRT), and anti-tumor hormone therapy, such as tamoxifen, on the physiological uptake of the endometrium on 2-deoxy-2[
18
F]fluoro-
d
-glucose ([
18
F]F-FDG) positron emission tomography (PET) in postmenopausal women have not been determined. We explored the effect of hormone therapy, particularly HRT, on physiological uptake in the endometrium of postmenopausal women.
Materials and methods
Postmenopausal women receiving hormone therapy who underwent cancer screening using PET/computed tomography (CT) between June 2016 and April 2023 were included in the hormone therapy group (
n
= 21). Postmenopausal women with no history of hormone therapy were included in the control group (
n
= 49). First, the physiological endometrial uptake at menopausal age and at least 1 year thereafter was compared quantitatively (SUVmax) and qualitatively (4-point scale) in the control group, to assess when the endometrium ceased to show significant physiological [
18
F]F-FDG uptake after menopause. Endometrial uptake was compared between the hormone therapy and control groups. The association between HRT duration (months) and endometrial uptake (SUVmax) was evaluated. Endometrial thickness, measured using transvaginal ultrasonography, was also compared between the two groups.
Results
Endometrial uptake was significantly reduced both qualitatively and quantitatively (
P
|
| doi_str_mv | 10.1007/s12149-024-01941-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3095597512</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3095597512</sourcerecordid><originalsourceid>FETCH-LOGICAL-c293t-e7229f5ef70840be4456a72a1c55d94397c5f8baaa8889f6f6b0fb99e285c71e3</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhi0EokvhD3BAlji7ePwR20dUui1SJThsTxWynOy4m7KJg50I7b_Hyxa4cZrDPM87mpeQt8AvgHPzoYAA5RgXinFwCph-RlZgG8UaJeVzsuIOFDNgzRl5Vcoj58JqK16SM2lNAxJgRfJmhxRjxG6mKdJdykMakc47zGE60DTSaXcofdqnh74Le7pMc_iOR3Q-iuM2DTjnfhmO6D3Y9bc1W3-6pl-vNrSvcirzgGOawlKq_bPS42vyIoZ9wTdP85zcra82lzfs9sv158uPt6wTTs4MjRAuaoyGW8VbVEo3wYgAndZbp6QznY62DSFYa11sYtPy2DqH9cnOAMpz8v6UO-X0Y8Ey-8e05LGe9JI7rZ3RIColTlSXUykZo59yP4R88MD9sWZ_qtnXmv3vmr2u0run6KUdcPtX-dNrBeQJKHU1PmD-d_s_sb8Am7eIIg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3095597512</pqid></control><display><type>article</type><title>The effect of hormone therapy on physiological uptake of the endometrium on [18F]F-FDG PET in postmenopausal women</title><source>Springer Link</source><creator>Nakamoto, Ryusuke ; Yakami, Masahiro ; Nobashi, Tomomi W. ; Isoda, Hiroyoshi ; Nakamoto, Yuji</creator><creatorcontrib>Nakamoto, Ryusuke ; Yakami, Masahiro ; Nobashi, Tomomi W. ; Isoda, Hiroyoshi ; Nakamoto, Yuji</creatorcontrib><description>Objective
The effects of hormonal therapy, estrogen-based hormone replacement therapy (HRT), and anti-tumor hormone therapy, such as tamoxifen, on the physiological uptake of the endometrium on 2-deoxy-2[
18
F]fluoro-
d
-glucose ([
18
F]F-FDG) positron emission tomography (PET) in postmenopausal women have not been determined. We explored the effect of hormone therapy, particularly HRT, on physiological uptake in the endometrium of postmenopausal women.
Materials and methods
Postmenopausal women receiving hormone therapy who underwent cancer screening using PET/computed tomography (CT) between June 2016 and April 2023 were included in the hormone therapy group (
n
= 21). Postmenopausal women with no history of hormone therapy were included in the control group (
n
= 49). First, the physiological endometrial uptake at menopausal age and at least 1 year thereafter was compared quantitatively (SUVmax) and qualitatively (4-point scale) in the control group, to assess when the endometrium ceased to show significant physiological [
18
F]F-FDG uptake after menopause. Endometrial uptake was compared between the hormone therapy and control groups. The association between HRT duration (months) and endometrial uptake (SUVmax) was evaluated. Endometrial thickness, measured using transvaginal ultrasonography, was also compared between the two groups.
Results
Endometrial uptake was significantly reduced both qualitatively and quantitatively (
P
< 0.05) at least 1 year after menopause in control patients, by which time most women (89.8%) no longer had significant endometrial uptake. The hormone therapy group (
n
= 21) showed higher FDG uptake in the endometrium compared to the control group (median SUVmax: 2.3 vs 1.9,
P
= 0.0011), as well as a higher visual score (
P
< 0.0001). HRT duration did not correlate with endometrial uptake (
P
= 0.097). Endometrial thickness in the hormone therapy group was significantly thicker than in the control group (median: 3.9 mm vs 1.8 mm,
P
= 0.002).
Conclusion
Hormone therapy may affect physiological uptake in the endometrium in postmenopausal women.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-024-01941-5</identifier><identifier>PMID: 38761311</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Aged ; Biological Transport - drug effects ; Cancer screening ; Computed tomography ; Endocrine therapy ; Endometrium ; Endometrium - diagnostic imaging ; Endometrium - drug effects ; Endometrium - metabolism ; Estrogens ; Female ; Fluorine isotopes ; Fluorodeoxyglucose F18 - metabolism ; Glucose ; Hormone Replacement Therapy ; Humans ; Imaging ; Medical screening ; Medicine ; Medicine & Public Health ; Menopause ; Middle Aged ; Nuclear Medicine ; Original Article ; Physiological effects ; Physiology ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography ; Post-menopause ; Postmenopause ; Radiology ; Retrospective Studies ; Therapy ; Thickness measurement ; Tomography</subject><ispartof>Annals of nuclear medicine, 2024-09, Vol.38 (9), p.726-733</ispartof><rights>The Author(s), under exclusive licence to The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine.</rights><rights>The Author(s), under exclusive licence to The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c293t-e7229f5ef70840be4456a72a1c55d94397c5f8baaa8889f6f6b0fb99e285c71e3</cites><orcidid>0000-0003-4950-6654</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38761311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamoto, Ryusuke</creatorcontrib><creatorcontrib>Yakami, Masahiro</creatorcontrib><creatorcontrib>Nobashi, Tomomi W.</creatorcontrib><creatorcontrib>Isoda, Hiroyoshi</creatorcontrib><creatorcontrib>Nakamoto, Yuji</creatorcontrib><title>The effect of hormone therapy on physiological uptake of the endometrium on [18F]F-FDG PET in postmenopausal women</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><addtitle>Ann Nucl Med</addtitle><description>Objective
The effects of hormonal therapy, estrogen-based hormone replacement therapy (HRT), and anti-tumor hormone therapy, such as tamoxifen, on the physiological uptake of the endometrium on 2-deoxy-2[
18
F]fluoro-
d
-glucose ([
18
F]F-FDG) positron emission tomography (PET) in postmenopausal women have not been determined. We explored the effect of hormone therapy, particularly HRT, on physiological uptake in the endometrium of postmenopausal women.
Materials and methods
Postmenopausal women receiving hormone therapy who underwent cancer screening using PET/computed tomography (CT) between June 2016 and April 2023 were included in the hormone therapy group (
n
= 21). Postmenopausal women with no history of hormone therapy were included in the control group (
n
= 49). First, the physiological endometrial uptake at menopausal age and at least 1 year thereafter was compared quantitatively (SUVmax) and qualitatively (4-point scale) in the control group, to assess when the endometrium ceased to show significant physiological [
18
F]F-FDG uptake after menopause. Endometrial uptake was compared between the hormone therapy and control groups. The association between HRT duration (months) and endometrial uptake (SUVmax) was evaluated. Endometrial thickness, measured using transvaginal ultrasonography, was also compared between the two groups.
Results
Endometrial uptake was significantly reduced both qualitatively and quantitatively (
P
< 0.05) at least 1 year after menopause in control patients, by which time most women (89.8%) no longer had significant endometrial uptake. The hormone therapy group (
n
= 21) showed higher FDG uptake in the endometrium compared to the control group (median SUVmax: 2.3 vs 1.9,
P
= 0.0011), as well as a higher visual score (
P
< 0.0001). HRT duration did not correlate with endometrial uptake (
P
= 0.097). Endometrial thickness in the hormone therapy group was significantly thicker than in the control group (median: 3.9 mm vs 1.8 mm,
P
= 0.002).
Conclusion
Hormone therapy may affect physiological uptake in the endometrium in postmenopausal women.</description><subject>Aged</subject><subject>Biological Transport - drug effects</subject><subject>Cancer screening</subject><subject>Computed tomography</subject><subject>Endocrine therapy</subject><subject>Endometrium</subject><subject>Endometrium - diagnostic imaging</subject><subject>Endometrium - drug effects</subject><subject>Endometrium - metabolism</subject><subject>Estrogens</subject><subject>Female</subject><subject>Fluorine isotopes</subject><subject>Fluorodeoxyglucose F18 - metabolism</subject><subject>Glucose</subject><subject>Hormone Replacement Therapy</subject><subject>Humans</subject><subject>Imaging</subject><subject>Medical screening</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Physiological effects</subject><subject>Physiology</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Post-menopause</subject><subject>Postmenopause</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Therapy</subject><subject>Thickness measurement</subject><subject>Tomography</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhi0EokvhD3BAlji7ePwR20dUui1SJThsTxWynOy4m7KJg50I7b_Hyxa4cZrDPM87mpeQt8AvgHPzoYAA5RgXinFwCph-RlZgG8UaJeVzsuIOFDNgzRl5Vcoj58JqK16SM2lNAxJgRfJmhxRjxG6mKdJdykMakc47zGE60DTSaXcofdqnh74Le7pMc_iOR3Q-iuM2DTjnfhmO6D3Y9bc1W3-6pl-vNrSvcirzgGOawlKq_bPS42vyIoZ9wTdP85zcra82lzfs9sv158uPt6wTTs4MjRAuaoyGW8VbVEo3wYgAndZbp6QznY62DSFYa11sYtPy2DqH9cnOAMpz8v6UO-X0Y8Ey-8e05LGe9JI7rZ3RIColTlSXUykZo59yP4R88MD9sWZ_qtnXmv3vmr2u0run6KUdcPtX-dNrBeQJKHU1PmD-d_s_sb8Am7eIIg</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Nakamoto, Ryusuke</creator><creator>Yakami, Masahiro</creator><creator>Nobashi, Tomomi W.</creator><creator>Isoda, Hiroyoshi</creator><creator>Nakamoto, Yuji</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0003-4950-6654</orcidid></search><sort><creationdate>20240901</creationdate><title>The effect of hormone therapy on physiological uptake of the endometrium on [18F]F-FDG PET in postmenopausal women</title><author>Nakamoto, Ryusuke ; Yakami, Masahiro ; Nobashi, Tomomi W. ; Isoda, Hiroyoshi ; Nakamoto, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-e7229f5ef70840be4456a72a1c55d94397c5f8baaa8889f6f6b0fb99e285c71e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Biological Transport - drug effects</topic><topic>Cancer screening</topic><topic>Computed tomography</topic><topic>Endocrine therapy</topic><topic>Endometrium</topic><topic>Endometrium - diagnostic imaging</topic><topic>Endometrium - drug effects</topic><topic>Endometrium - metabolism</topic><topic>Estrogens</topic><topic>Female</topic><topic>Fluorine isotopes</topic><topic>Fluorodeoxyglucose F18 - metabolism</topic><topic>Glucose</topic><topic>Hormone Replacement Therapy</topic><topic>Humans</topic><topic>Imaging</topic><topic>Medical screening</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Physiological effects</topic><topic>Physiology</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Post-menopause</topic><topic>Postmenopause</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Therapy</topic><topic>Thickness measurement</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamoto, Ryusuke</creatorcontrib><creatorcontrib>Yakami, Masahiro</creatorcontrib><creatorcontrib>Nobashi, Tomomi W.</creatorcontrib><creatorcontrib>Isoda, Hiroyoshi</creatorcontrib><creatorcontrib>Nakamoto, Yuji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamoto, Ryusuke</au><au>Yakami, Masahiro</au><au>Nobashi, Tomomi W.</au><au>Isoda, Hiroyoshi</au><au>Nakamoto, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of hormone therapy on physiological uptake of the endometrium on [18F]F-FDG PET in postmenopausal women</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><addtitle>Ann Nucl Med</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>38</volume><issue>9</issue><spage>726</spage><epage>733</epage><pages>726-733</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Objective
The effects of hormonal therapy, estrogen-based hormone replacement therapy (HRT), and anti-tumor hormone therapy, such as tamoxifen, on the physiological uptake of the endometrium on 2-deoxy-2[
18
F]fluoro-
d
-glucose ([
18
F]F-FDG) positron emission tomography (PET) in postmenopausal women have not been determined. We explored the effect of hormone therapy, particularly HRT, on physiological uptake in the endometrium of postmenopausal women.
Materials and methods
Postmenopausal women receiving hormone therapy who underwent cancer screening using PET/computed tomography (CT) between June 2016 and April 2023 were included in the hormone therapy group (
n
= 21). Postmenopausal women with no history of hormone therapy were included in the control group (
n
= 49). First, the physiological endometrial uptake at menopausal age and at least 1 year thereafter was compared quantitatively (SUVmax) and qualitatively (4-point scale) in the control group, to assess when the endometrium ceased to show significant physiological [
18
F]F-FDG uptake after menopause. Endometrial uptake was compared between the hormone therapy and control groups. The association between HRT duration (months) and endometrial uptake (SUVmax) was evaluated. Endometrial thickness, measured using transvaginal ultrasonography, was also compared between the two groups.
Results
Endometrial uptake was significantly reduced both qualitatively and quantitatively (
P
< 0.05) at least 1 year after menopause in control patients, by which time most women (89.8%) no longer had significant endometrial uptake. The hormone therapy group (
n
= 21) showed higher FDG uptake in the endometrium compared to the control group (median SUVmax: 2.3 vs 1.9,
P
= 0.0011), as well as a higher visual score (
P
< 0.0001). HRT duration did not correlate with endometrial uptake (
P
= 0.097). Endometrial thickness in the hormone therapy group was significantly thicker than in the control group (median: 3.9 mm vs 1.8 mm,
P
= 0.002).
Conclusion
Hormone therapy may affect physiological uptake in the endometrium in postmenopausal women.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>38761311</pmid><doi>10.1007/s12149-024-01941-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4950-6654</orcidid></addata></record> |
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| issn | 0914-7187 1864-6433 |
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| source | Springer Link |
| subjects | Aged Biological Transport - drug effects Cancer screening Computed tomography Endocrine therapy Endometrium Endometrium - diagnostic imaging Endometrium - drug effects Endometrium - metabolism Estrogens Female Fluorine isotopes Fluorodeoxyglucose F18 - metabolism Glucose Hormone Replacement Therapy Humans Imaging Medical screening Medicine Medicine & Public Health Menopause Middle Aged Nuclear Medicine Original Article Physiological effects Physiology Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography Post-menopause Postmenopause Radiology Retrospective Studies Therapy Thickness measurement Tomography |
| title | The effect of hormone therapy on physiological uptake of the endometrium on [18F]F-FDG PET in postmenopausal women |
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