Small‐Bandgap Transducers Induced Carrier Separation for In Situ Dual‐Amplified Tumor Oxidative Stress

The inherent and unique charge‐carrier release characteristics of piezoelectric sonosensitizers with desired bandgap can be leveraged to initiate reactive oxygen species (ROS) reactions that have considerable potential for sonodynamic therapy (SDT). In this study, a bimetallic Bi4NbO8Br‐polyvinylpyr...

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Bibliographic Details
Published in:Advanced functional materials 2024-08, Vol.34 (34), p.n/a
Main Authors: Hu, Guangyao, Wang, Jiarui, Chen, Lulu, Zheng, Haoqin, Lan, Yuanpei, Wang, Kaiyang, Liu, Xijian, You, Hongpeng, Luo, Yu, Dong, Lile
Format: Article
Language:English
Subjects:
Bi4NbO8Br
bimetallic
Bimetals
Current carriers
Energy gap
Glutathione
piezoelectric
Piezoelectricity
Polyvinylpyrrolidone
Separation
small bandgap
sonosensitizers
Titanium dioxide
Tumors
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Summary:The inherent and unique charge‐carrier release characteristics of piezoelectric sonosensitizers with desired bandgap can be leveraged to initiate reactive oxygen species (ROS) reactions that have considerable potential for sonodynamic therapy (SDT). In this study, a bimetallic Bi4NbO8Br‐polyvinylpyrrolidone (BNOBP) with a small bandgap (2.45 eV) is synthesized as a potential piezoelectric sonosensitizer. The robust interactions within and between the Bi─O and Nb─O layers narrow the bandgap, facilitating carrier transfer. Concurrently, compared with that of TiO2 and BiOBr, BNOBP exhibits a rapid acoustoelectric response and desirable electron–hole separation efficiency, enabling the generation of ·O2− under ultrasound (US) irradiation. Notably, BNOBP alleviates the overexpression of glutathione (GSH) in tumors and prevents the consumption of the generated ROS by GSH. Combining the previous small bandgap endow the high ROS generation efficiency, this study provides a paradigm for in situ regulation of oxidative stress levels in tumor tissue microenvironment based on bimetallic piezoelectric sonosensitizers. Herein, bimetallic small bandgap BNOBP piezoelectric sonosensitizer exhibits acceptable tumor suppression capability. On one hand, the robust interactions within and between the Bi─O and Nb─O layers narrow the bandgap, facilitating carrier transfer. On the other hand, BNOBP exhibits a rapid acoustoelectric response and desirable electron–hole separation efficiency, enabling the generation of ·O2− under ultrasound irradiation.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202401897