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Hadron therapy in radiation oncology and why BNCT is a paradigm shift
Purpose Hadrons, i.e. particles that are heavier than electrons, are playing an increasingly important role in radiation oncology. Due to the high investment costs for the necessary infrastructure, this option is only available in specialized centers. Methods This article describes some of the physi...
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| Published in: | Health and technology 2024-09, Vol.14 (5), p.995-1000 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c319t-4204b47b10dd72b02bc918dcadb880162d9931598d209012374e224aa1e7921a3 |
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| cites | cdi_FETCH-LOGICAL-c319t-4204b47b10dd72b02bc918dcadb880162d9931598d209012374e224aa1e7921a3 |
| container_end_page | 1000 |
| container_issue | 5 |
| container_start_page | 995 |
| container_title | Health and technology |
| container_volume | 14 |
| creator | Sauerwein, Wolfgang A. G. Igawa, Kazuyo Herault, Joël Fossati, Piero Altieri, Saverio Moss, Raymond L. Wittig, Andrea |
| description | Purpose
Hadrons, i.e. particles that are heavier than electrons, are playing an increasingly important role in radiation oncology. Due to the high investment costs for the necessary infrastructure, this option is only available in specialized centers.
Methods
This article describes some of the physical properties that make hadrons attractive for external beam radiation therapy (EBRT), but also some of the challenges that need to be considered.
Results
The importance of linear energy transfer for biological effects is discussed.
Conclusions
In addition to the use of charged particles, the importance of neutrons for radiotherapy is also highlighted, in particular the properties of boron neutron capture therapy (BNCT), which open up completely new possibilities for the further development of EBRT. |
| doi_str_mv | 10.1007/s12553-024-00848-5 |
| format | article |
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Hadrons, i.e. particles that are heavier than electrons, are playing an increasingly important role in radiation oncology. Due to the high investment costs for the necessary infrastructure, this option is only available in specialized centers.
Methods
This article describes some of the physical properties that make hadrons attractive for external beam radiation therapy (EBRT), but also some of the challenges that need to be considered.
Results
The importance of linear energy transfer for biological effects is discussed.
Conclusions
In addition to the use of charged particles, the importance of neutrons for radiotherapy is also highlighted, in particular the properties of boron neutron capture therapy (BNCT), which open up completely new possibilities for the further development of EBRT.</description><identifier>ISSN: 2190-7188</identifier><identifier>EISSN: 2190-7196</identifier><identifier>DOI: 10.1007/s12553-024-00848-5</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Atoms & subatomic particles ; Biological and Medical Physics ; Biological effects ; Biological properties ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Cancer therapies ; Carbon ; Charged particles ; Clinical medicine ; Computational Biology/Bioinformatics ; Energy ; Engineering ; Hadrons ; Hadrontherapy and BNCT: Current Status and Future Trends ; Helium ; Hypoxia ; Linear energy transfer (LET) ; Medicine/Public Health ; Neutrons ; Nuclear capture ; Oncology ; Original Paper ; Particle physics ; Physical properties ; Protons ; R & D/Technology Policy ; Radiation therapy ; Tumors</subject><ispartof>Health and technology, 2024-09, Vol.14 (5), p.995-1000</ispartof><rights>The Author(s) 2024</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-4204b47b10dd72b02bc918dcadb880162d9931598d209012374e224aa1e7921a3</citedby><cites>FETCH-LOGICAL-c319t-4204b47b10dd72b02bc918dcadb880162d9931598d209012374e224aa1e7921a3</cites><orcidid>0000-0002-5027-5913</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Sauerwein, Wolfgang A. G.</creatorcontrib><creatorcontrib>Igawa, Kazuyo</creatorcontrib><creatorcontrib>Herault, Joël</creatorcontrib><creatorcontrib>Fossati, Piero</creatorcontrib><creatorcontrib>Altieri, Saverio</creatorcontrib><creatorcontrib>Moss, Raymond L.</creatorcontrib><creatorcontrib>Wittig, Andrea</creatorcontrib><title>Hadron therapy in radiation oncology and why BNCT is a paradigm shift</title><title>Health and technology</title><addtitle>Health Technol</addtitle><description>Purpose
Hadrons, i.e. particles that are heavier than electrons, are playing an increasingly important role in radiation oncology. Due to the high investment costs for the necessary infrastructure, this option is only available in specialized centers.
Methods
This article describes some of the physical properties that make hadrons attractive for external beam radiation therapy (EBRT), but also some of the challenges that need to be considered.
Results
The importance of linear energy transfer for biological effects is discussed.
Conclusions
In addition to the use of charged particles, the importance of neutrons for radiotherapy is also highlighted, in particular the properties of boron neutron capture therapy (BNCT), which open up completely new possibilities for the further development of EBRT.</description><subject>Atoms & subatomic particles</subject><subject>Biological and Medical Physics</subject><subject>Biological effects</subject><subject>Biological properties</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Cancer therapies</subject><subject>Carbon</subject><subject>Charged particles</subject><subject>Clinical medicine</subject><subject>Computational Biology/Bioinformatics</subject><subject>Energy</subject><subject>Engineering</subject><subject>Hadrons</subject><subject>Hadrontherapy and BNCT: Current Status and Future Trends</subject><subject>Helium</subject><subject>Hypoxia</subject><subject>Linear energy transfer (LET)</subject><subject>Medicine/Public Health</subject><subject>Neutrons</subject><subject>Nuclear capture</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Particle physics</subject><subject>Physical properties</subject><subject>Protons</subject><subject>R & D/Technology Policy</subject><subject>Radiation therapy</subject><subject>Tumors</subject><issn>2190-7188</issn><issn>2190-7196</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kEFPwzAMhSMEEtPYH-AUiXPBcZIlOcI0GNIEl3GO0qbbOm1tSTqh_nuyFcENX2xZ7z1bHyG3DO4ZgHqIDKXkGaDIALTQmbwgI2QGMsXM9PJ31vqaTGLcQSrJpBF8ROYL50NT025bBtf2tKppcL5yXZWWTV00-2bTU1d7-rXt6dPbbEWrSB1t3Um2OdC4rdbdDblau30sJz99TD6e56vZIlu-v7zOHpdZwZnpMoEgcqFyBt4rzAHzwjDtC-dzrYFN0RvD02PaIxhgyJUoEYVzrFQGmeNjcjfktqH5PJaxs7vmGOp00nIwCjVKPU0qHFRFaGIM5dq2oTq40FsG9kTMDsRsImbPxKxMJj6YYhLXmzL8Rf_j-galL2uN</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Sauerwein, Wolfgang A. 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G.</creatorcontrib><creatorcontrib>Igawa, Kazuyo</creatorcontrib><creatorcontrib>Herault, Joël</creatorcontrib><creatorcontrib>Fossati, Piero</creatorcontrib><creatorcontrib>Altieri, Saverio</creatorcontrib><creatorcontrib>Moss, Raymond L.</creatorcontrib><creatorcontrib>Wittig, Andrea</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Health and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sauerwein, Wolfgang A. 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Hadrons, i.e. particles that are heavier than electrons, are playing an increasingly important role in radiation oncology. Due to the high investment costs for the necessary infrastructure, this option is only available in specialized centers.
Methods
This article describes some of the physical properties that make hadrons attractive for external beam radiation therapy (EBRT), but also some of the challenges that need to be considered.
Results
The importance of linear energy transfer for biological effects is discussed.
Conclusions
In addition to the use of charged particles, the importance of neutrons for radiotherapy is also highlighted, in particular the properties of boron neutron capture therapy (BNCT), which open up completely new possibilities for the further development of EBRT.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s12553-024-00848-5</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5027-5913</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Health and technology, 2024-09, Vol.14 (5), p.995-1000 |
| issn | 2190-7188 2190-7196 |
| language | eng |
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| source | Springer Nature |
| subjects | Atoms & subatomic particles Biological and Medical Physics Biological effects Biological properties Biomedical Engineering and Bioengineering Biomedicine Biophysics Cancer therapies Carbon Charged particles Clinical medicine Computational Biology/Bioinformatics Energy Engineering Hadrons Hadrontherapy and BNCT: Current Status and Future Trends Helium Hypoxia Linear energy transfer (LET) Medicine/Public Health Neutrons Nuclear capture Oncology Original Paper Particle physics Physical properties Protons R & D/Technology Policy Radiation therapy Tumors |
| title | Hadron therapy in radiation oncology and why BNCT is a paradigm shift |
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