Palladium-catalysed directed remote meta -C–H functionalization of arenes using a cyclopentenyl-pyridyl template

Achieving positionally selective distal C–H functionalization remains a fundamental and longstanding challenge in the field of C–H activation. The directing template strategy has emerged as a promising solution to this problem. Herein, we disclose the development of a novel non-aromatic meta -select...

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Bibliographic Details
Published in:New journal of chemistry 2024-08, Vol.48 (34), p.15172-15178
Main Authors: Huang, Jun, Tang, Jinghong, Yan, Yifei, Liu, Zelin, He, Siquan, Jin, Zhong
Format: Article
Language:English
Subjects:
Aromatic compounds
Benzyl alcohol
Deuteration
Palladium
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Summary:Achieving positionally selective distal C–H functionalization remains a fundamental and longstanding challenge in the field of C–H activation. The directing template strategy has emerged as a promising solution to this problem. Herein, we disclose the development of a novel non-aromatic meta -selective directing template, which showed eminent reactivity and site-selectivity in palladium-catalyzed remote meta -C–H olefination, deuteration and acetoxylation of benzyl alcohols.
ISSN:1144-0546
1369-9261
DOI:10.1039/D4NJ02945C