Exploring the Bioactive Properties of Hydroethanolic Cork Extracts of Quercus cerris and Quercus suber

The bioactive properties of underutilized corks such as Quercus cerris cork and planted Quercus suber cork in the Eastern Mediterranean are not well-known but are crucial in developing lignocellulosic biorefineries. To assess their biological potential, hydroethanolic cork extracts of Quercus cerris...

Full description

Saved in:
Bibliographic Details
Published in:Processes 2024-08, Vol.12 (8), p.1579
Main Authors: Sen, Umut, Almeida, Daiana, da Silveira, Tayse F. F., Pires, Tânia S. P., Añibarro-Ortega, Mikel, Mandim, Filipa, Barros, Lillian, Ferreira, Isabel C. F. R., Pereira, Helena, Fernandes, Ângela
Format: Article
Language:English
Subjects:
Antimicrobial agents
Antioxidants
Antiproliferatives
Biological activity
Biological properties
Biorefineries
Cancer
Cell culture
Chromatography
Colon cancer
Composition
Cork
Hepatotoxicity
Lignocellulose
Lipid peroxidation
Phenolic acids
Phenols
Quercus cerris
Quercus suber
Refining
Trees
Tumor cell lines
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The bioactive properties of underutilized corks such as Quercus cerris cork and planted Quercus suber cork in the Eastern Mediterranean are not well-known but are crucial in developing lignocellulosic biorefineries. To assess their biological potential, hydroethanolic cork extracts of Quercus cerris and Quercus suber were analyzed for phenolic composition, antioxidant, antiproliferative, antimicrobial activities, and hepatoxicity, as well as NO-production inhibition. Here, we show that a mild hydroethanolic extraction of Q. cerris and Q. suber corks yielded 3% phenolic extracts. The phenolic composition was similar in both cork extracts, with phenolic acids and ellagitannins as the primary compounds. The bioactivity of hydroethanolic cork extracts from Q. cerris surpassed that of Q. suber and showed effectiveness against all cancer cell lines tested. This first comprehensive study on the bioactivities of different corks involves detailed characterizations of phenolic compounds of cork extracts using UPLC-DAD-ESI/MSn, evaluations of the antioxidant properties with TBARS and OxHLIA methods, evaluation of antiproliferative activity against gastric (AGS), lung (NCI-H460), colon (CaCo2), and breast cancer (MCF7) cell lines, as well as evaluations of hepatotoxicity and NO-production inhibition. The findings from this study will help bolster the potential of using underutilized cork-rich barks as a valuable resource in bark-based biorefineries.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr12081579