Hantzsch Synthesis of the Calcium Channel Blockers Nifedipine, Diludine, and Nitrendipine Using Methanesulfonic Acid as Catalyst

A simple and efficient one-pot three-component method has been developed and applied for the preparation of the calcium channel blockers nifedipine, diludine, and nitrendipine via Hantzsch dihydropyridine synthesis in good yields employing methanesulfonic acid as catalyst. The protocol stands out fo...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2024-06, Vol.60 (6), p.1117-1122
Main Authors: Potdar, S. M., Gurav, S. S., Raskar, S. V., Waghmode, K. T.
Format: Article
Language:English
Subjects:
Calcium channel blockers
Catalysts
Chemical synthesis
Chemistry
Chemistry and Materials Science
Methanesulfonic acid
Organic Chemistry
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Summary:A simple and efficient one-pot three-component method has been developed and applied for the preparation of the calcium channel blockers nifedipine, diludine, and nitrendipine via Hantzsch dihydropyridine synthesis in good yields employing methanesulfonic acid as catalyst. The protocol stands out for mild reaction conditions, shorter reaction time, high yield, and easy workup and purification procedures, which enhance its practicality. Furthermore, the use of inexpensive and greener catalyst contributes to the efficacy and feasibility of the presented synthetic approach.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428024060162