Modern electrosynthesis of spiro compounds

Spirocyclic scaffolds have received increasing interest because of their wide use in medicinal chemistry and the need for designing new effective drugs on their basis. Electroorganic synthesis is an environmentally friendly method for the preparation of organic compounds because hazardous and toxic...

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Bibliographic Details
Published in:Russian chemical bulletin 2024-07, Vol.73 (7), p.1845-1865
Main Authors: Elinson, M. N., Ryzhkova, Yu. E., Ryzhkov, F. V., Kalashnikova, V. M., Egorov, M. P.
Format: Article
Language:English
Subjects:
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cost analysis
Energy costs
Inorganic Chemistry
Organic Chemistry
Organic compounds
Reagents
Reviews
Spiro compounds
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Summary:Spirocyclic scaffolds have received increasing interest because of their wide use in medicinal chemistry and the need for designing new effective drugs on their basis. Electroorganic synthesis is an environmentally friendly method for the preparation of organic compounds because hazardous and toxic redox reagents are replaced by electric current and the overall energy costs are reduced. Modern methods for the electrosynthesis of spiro compounds and the prospects of their development are analyzed. The review summarizes the data on the types of electrochemical and electrocatalytic methods. The potential practical applications of these methods for the preparation of individual classes of spirocycles are discussed.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-024-4303-x