Fabrication and in vitro characterization of delafloxacin-laden electrosprayed hydroxypropyl cellulose nanoparticulated solid dispersions for enhanced aqueous solubility and release rate of the drug

With the aim of fabricating and characterizing an optimized drug delivery system (DDS) for an effective administration of poorly water-soluble delafloxacin (DFX) via the oral route, several formulations of delafloxacin-laden solid dispersions (SD) were prepared employing the solvent-evaporation and...

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Bibliographic Details
Published in:International journal of polymeric materials 2024-11, Vol.73 (16), p.1367-1373
Main Authors: Ramzan, Muhammad, Yousaf, Abid Mehmood, Khan, Ikram Ullah
Format: Article
Language:English
Subjects:
delafloxacin
Dispersions
Drug delivery systems
Electrospraying
Evaporation rate
Fourier transforms
Hydroxypropyl cellulose
Infrared analysis
nanoparticles
solid dispersions
Solubility
Spherical powders
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Summary:With the aim of fabricating and characterizing an optimized drug delivery system (DDS) for an effective administration of poorly water-soluble delafloxacin (DFX) via the oral route, several formulations of delafloxacin-laden solid dispersions (SD) were prepared employing the solvent-evaporation and electrospraying techniques concomitantly. Solubility and release rate of the drug in the SD were assessed. Solid-state characterization was performed via the X-ray diffraction (PXRD) and differential scanning calorimetric (DSC) analyses, scanning electron microscopy (SEM) and Fourier transform infrared spectroscopic (FTIR) analysis. Amongst the prepared SD, an optimized formulation consisting of DFX, HPC, and SLS at the weight ratio of (1/8/0.2) showed about 9-fold higher solubility and 13-fold faster release rate of delafloxacin as compared to delafloxacin plain drug powder (DPDP). The drug existed in the amorphous form in the spherical particles and had no covalent interaction with any of the excipients. Thus, this optimized formulation might be a useful DDS for an effective administration of DFX.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2023.2289521