The modulatory influence of humic acid on cognitive impairment and neurobehavioral changes induced by colitis in adult male Wistar rats

Ulcerative colitis (UC) is a chronic inflammatory disorder that affects any part of the colon. UC often coexists with neuropsychiatric symptoms like anxiety, depression, and cognitive impairment. Current drugs for managing UC have adverse effects and are ineffective against these comorbid conditions...

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Published in:Nutrire : revista de Sociedade Brasileira de Alimentação e Nutrição = journal of the Brazilian Society of Food and Nutrition 2024-09, Vol.49 (2), p.46, Article 46
Main Authors: Omolaso, Blessing Oluwagbamila, Ogunmiluyi, Oluwafunmbi Ebenezer, Adeniran, Adeoti Gbemisola, Adesanwo, Julius Kolawole, Akinlaja, Divine Olanrewaju
Format: Article
Language:English
Subjects:
Acids
Clinical Nutrition
Cognitive ability
Food Science
Inflammatory bowel disease
Medicine
Medicine & Public Health
Nutrition
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Summary:Ulcerative colitis (UC) is a chronic inflammatory disorder that affects any part of the colon. UC often coexists with neuropsychiatric symptoms like anxiety, depression, and cognitive impairment. Current drugs for managing UC have adverse effects and are ineffective against these comorbid conditions. While recent studies suggest humic acid may offer novel benefits, there is a notable gap in the literature on its effects on colitis-induced neurobehavioral impairments. This study was conducted to investigate the role of humic acid (HA) in attenuating neurobehavioral disorders caused by dextran sulfate sodium–induced ulcerative colitis in male Wistar rats. Methods Twenty male Wistar rats were randomly assigned into groups ( n  = 5). Group 1 [control group]; group 2 [5% dextran sulfate sodium (DSS) without any additional treatment]; group 3 [5% DSS followed by administration of humic acid (30 mg/kg)]; group 4 [5% DSS followed by administration of sulfasalazine (200 mg/kg)]. The behavioral patterns of the rats were assessed pre-colitis induction, immediately after colitis induction on day 5, and immediately after drug treatment for ulcerative colitis (post-treatment). The disease activity index (DAI) for colitis was obtained on days 1, 3, 5, and 10 of the experimental duration. Thereafter, the brains were harvested for biochemical assays. Data were analyzed using ANOVA at p  
ISSN:2316-7874
1519-8928
2316-7874
DOI:10.1186/s41110-024-00286-3