Preparation of Hydrophobic Bovine-Serum-Albumin-capped Gold Nanoclusters and Encapsulation in Polystyrene Nanoparticles

Metal-based nanoclusters (NCs) have unique physicochemical properties, and they have been applied to various fields. Gold NCs (Au NCs) show fluorescence ranging from blue to red under ultraviolet (UV) irradiation. Bovine-serum-albumin (BSA)-capped Au NCs (BSA-Au NCs) have specific fluorescence prope...

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Bibliographic Details
Published in:E-journal of surface science and nanotechnology 2024/02/10, Vol.22(2), pp.115-119
Main Authors: Ichimaru, Hiroaki, Hanazawa, Natsumi, Orita, Emina, Kikuchi, Shigetoshi
Format: Article
Language:eng ; jpn
Subjects:
Albumins
Biomedical materials
Cattle
Encapsulation
Fluorescence
Fluorescent nanoparticles
Gold
Gold nanoclusters
Hydrophilicity
Hydrophobic gold nanocluster
Hydrophobic interaction
Hydrophobicity
Irradiation
Nanoclusters
Nanoparticles
Polystyrene resins
Swelling method
Ultraviolet radiation
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Summary:Metal-based nanoclusters (NCs) have unique physicochemical properties, and they have been applied to various fields. Gold NCs (Au NCs) show fluorescence ranging from blue to red under ultraviolet (UV) irradiation. Bovine-serum-albumin (BSA)-capped Au NCs (BSA-Au NCs) have specific fluorescence properties, and they are expected to be used for biomedical applications. However, the environment of BSA-Au NCs is hydrophilic because hydrophilic BSA covers the Au NC surface, limiting their applications. To overcome this drawback, we developed hydrophobic BSA-Au NCs (h-BSA-Au NCs) using (formylmethyl)triphenylphosphonium chloride as the hydrophobic agent by reductive amination reaction. Resulting h-BSA-Au NCs were encapsulated in polystyrene nanoparticles (Au PS NPs) by the typical swelling method under mild conditions. The Au PS NPs showed orange fluorescence under UV irradiation. Therefore, Au PS NPs are promising fluorescent materials for biomedical applications.
ISSN:1348-0391
1348-0391
DOI:10.1380/ejssnt.2024-002