Synthesis of (bi)pyridine derivatives of ornidazole

New (bi)pyridine derivatives of the antimicrobial drug ornidazole were synthesized by alkylation of pyridyl- and 2,2′-bipyridyl-phenolic derivatives for the first time. The proposed methodology makes it possible to expand the range of ornidazole derivatives with increased antibacterial activity.

Saved in:
Bibliographic Details
Published in:Russian chemical bulletin 2024-08, Vol.73 (8), p.2298-2302
Main Authors: Kudryashova, E. A., Valieva, M. I., Slovesnova, N. V., Bolotova, A. V., Sayfutdinova, Yu. M., Vatolina, S. E., Nikonov, I. L., Grzhegorzhevskii, K. V., Kopchuk, D. S., Zyryanov, G. V., Rusinov, V. L.
Format: Article
Language:English
Subjects:
Alkylation
Antiinfectives and antibacterials
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
Pyridines
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:New (bi)pyridine derivatives of the antimicrobial drug ornidazole were synthesized by alkylation of pyridyl- and 2,2′-bipyridyl-phenolic derivatives for the first time. The proposed methodology makes it possible to expand the range of ornidazole derivatives with increased antibacterial activity.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-024-4352-1