Quantitative Detection of Rebamipide by Zero order UV-Spectrophotometry using Dimethyl Formamide Solvent System

A Simple, Accurate, precise and reproducible method has been developed for the estimation of Rebamipide in pharmaceuticalsby Zero order UV spectrophotometric method for quantitative estimation of zero order for the Rebamipide has been reported in the present work. In need to design a novel approach...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2024-07, Vol.17 (7), p.3353-3357
Main Authors: Karajgi, Santosh, Kulkarni, R. V., Potadar, Shripad, Ingale, Anand, Patil, Sudha, M, Chetan
Format: Article
Language:English
Subjects:
Accuracy
Brand names
Conflicts of interest
Drug dosages
Ethanol
Methods
Pharmaceuticals
Solvents
Spectrum analysis
Ulcers
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Summary:A Simple, Accurate, precise and reproducible method has been developed for the estimation of Rebamipide in pharmaceuticalsby Zero order UV spectrophotometric method for quantitative estimation of zero order for the Rebamipide has been reported in the present work. In need to design a novel approach to analyse the drug utilizing Dimethyl formamide as a solvent was identified. Rebamipide has absorbance maxima for zero order is 332nm in this solvent system. This drug follows beer’s law in concentration range of 20-200µg/ml. The recovery studies verified the proposed method's accuracy and findings were validated in accordance with ICH recommendations. The findings were deemed to be reliable and satisfactory. As a result, the suggested method can be used to quantitatively estimate Rebamipide in ordinary analysis work.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2024.00524