Regioselective Halogenation of 2‐Oxindoles and β‐Keto Esters Using Oxone‐Halide With or Without Aryl Iodine

Efficient and environmentally benign regioselective halogenation protocols have been achieved through the mediation of oxone‐halide, with or without the assistance of aryl iodine. The key to the success of the regioselectivity process is the controlled generation of the active [X]+ or halogen‐substi...

Full description

Saved in:
Bibliographic Details
Published in:European journal of organic chemistry 2024-09, Vol.27 (36), p.n/a
Main Authors: Dong, Yufei, Guo, Cheng, Bai, Yadi, Jia, Hongbo, Yang, Aohua, Ren, Jingyun
Format: Article
Language:English
Subjects:
Aromatic compounds
Esters
Fluorination
Halogenation
Hypervalent iodine
Iodine
Oxone oxidation
Regioselective halogenations
Regioselectivity
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Efficient and environmentally benign regioselective halogenation protocols have been achieved through the mediation of oxone‐halide, with or without the assistance of aryl iodine. The key to the success of the regioselectivity process is the controlled generation of the active [X]+ or halogen‐substituted hypervalent iodine (III) by manipulating the components of the oxone‐halide‐aryl iodine system. Environmentally friendly and regioselective halogenation protocols, especially green fluorination protocols of 2‐oxindoles and β‐keto esters are developed by manipulation of the components of the oxone‐halide‐aryl iodine system.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202400522