Nickel‐Catalyzed Regio‐ and Stereoselective Reductive Alkylative Cyclization of 1,6‐Enynes with Alkyl Bromides

A nickel‐catalyzed reductive alkylative cyclization of 1,6‐enynes with alkyl bromides has been developed. This transformation avoids the use of stoichiometric organometallic reagents and introduces alkyl groups regio‐ and stereoselectively into the products. This method provides a platform for the s...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2024-09, Vol.366 (18), p.3802-3807
Main Authors: Xing, Yunxin, Tian, Zhu, Shen, Kun
Format: Article
Language:English
Subjects:
1,6-enyne
Alkylation
Bromides
Chemical synthesis
Cyclization
Natural products
Nickel
Reagents
Reductive cross-coupling
Stereoselectivity
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A nickel‐catalyzed reductive alkylative cyclization of 1,6‐enynes with alkyl bromides has been developed. This transformation avoids the use of stoichiometric organometallic reagents and introduces alkyl groups regio‐ and stereoselectively into the products. This method provides a platform for the synthesis of carbo‐ and heterocycles that are widely found in many natural products and biologically active molecules.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202400575