anti -Dihydroxylation of olefins enabled by in situ generated peroxyacetic acid

Herein, we report a general and green protocol for the anti -dihydroxylation of unactivated alkenes. Combining H 2 O 2 and acetic acid at 50 °C results in the formation of peroxyacetic acid, which enables the efficient synthesis of a wide range of anti 1,2-diols in moderate to good yields without th...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2024-09, Vol.26 (19), p.10058-10063
Main Authors: Tapera, Michael, Chotia, Mohit, Mayer-Figge, Jan Lukas, Gómez-Suárez, Adrián, Kirsch, Stefan F.
Format: Article
Language:English
Subjects:
Acetic acid
Alkenes
Catalysts
Chemical synthesis
Diols
Hydrogen peroxide
Peracetic acid
Transition metals
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Summary:Herein, we report a general and green protocol for the anti -dihydroxylation of unactivated alkenes. Combining H 2 O 2 and acetic acid at 50 °C results in the formation of peroxyacetic acid, which enables the efficient synthesis of a wide range of anti 1,2-diols in moderate to good yields without the need for hazardous solvents or expensive transition metals as catalysts.
ISSN:1463-9262
1463-9270
DOI:10.1039/D4GC03540B