High‐performance aminosilane‐infused alginate capsules for sustained drug release

• Published in: Journal of applied polymer science 2024-10, Vol.141 (40), p.n/a
• Main Authors: Imanishi, Sora, Sawano, Yuji, Kurayama, Fumio, Shibata, Yuichi, Matsuyama, Tatsushi, Ida, Junichi
• Format: Article
• Language: English
• Subjects: Aminopropyltriethoxysilane; aminosilane; Bonding strength; capsule; Chemical bonds; controlled drug release; diclofenac sodium; Drug carriers; drug delivery system; Pore size; Porosity; Siloxanes; simulated gastrointestinal environment; Sodium alginate; Sustained release
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.56034

Sodium alginate (AlgNa) is often used to prepare oral drug capsules, offering the advantages of facile carrier formation and pH sensitivity. However, these capsules suffer from high porosity, large pore size, and mechanical and physiological instabilities. Although the performance of AlgNa in oral drug carriers can be enhanced through hybridization with other substances, this results in increased complexity and additional preparation steps. To address this problem, organic–inorganic hybrid capsules are herein prepared via the one‐step incorporation of aminosilanes (3‐aminopropyltriethoxysilane and 3‐(2‐aminoethylamino)propyltrimethoxysilane) into AlgNa and evaluated as delivery vehicles for the sustained release of a model drug, diclofenac sodium. The hybrid capsules show elevated drug encapsulation efficiencies (up to 92.7%) and pH responsiveness and outperform pure alginate capsules, exhibiting contraction and low release rates (