High-dose N-acetylcysteine in an immunocompromised patient with COVID-19: a case report

CC BY-NC-ND 4.0 CASE REPORT High-dose N-acetylcysteine in an immunocompromised patient with COVID-19: a case report KY Lai, FHKAM (Medicine), FRCP1; SY Au, FHKAM (Medicine), FRCP2; KC Sin, FHKAM (Medicine), FRCP1; SK Yung, FHKAM (Medicine), FRCP1; Anne KH Leung, FHKAM (Anaesthesiology), FJFICM1 1 De...

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Published in:Hong Kong medical journal = Xianggang yi xue za zhi 2024-02, Vol.30 (1), p.69
Main Authors: Lai, K Y, Au, S Y, Sin, K C, Yung, S K, Leung, A K H
Format: Article
Language:chi ; eng
Subjects:
Antioxidants
Case reports
COVID-19 vaccines
Cytokine storm
Drug dosages
Endoplasmic reticulum
Infections
Infectious diseases
Intensive care
Medicine
Monoclonal antibodies
Pneumonia
Proteins
Severe acute respiratory syndrome coronavirus 2
Swine flu
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Summary:CC BY-NC-ND 4.0 CASE REPORT High-dose N-acetylcysteine in an immunocompromised patient with COVID-19: a case report KY Lai, FHKAM (Medicine), FRCP1; SY Au, FHKAM (Medicine), FRCP2; KC Sin, FHKAM (Medicine), FRCP1; SK Yung, FHKAM (Medicine), FRCP1; Anne KH Leung, FHKAM (Anaesthesiology), FJFICM1 1 Department of Intensive Care, Queen Elizabeth Hospital, Hong Kong SAR, China 2 Cardiovascular Centre, St Paul's Hospital, Hong Kong SAR, China Corresponding author: When the patient showed no signs of viral clearance on 26 June 2022 and antibodies against SARS-CoV-2 remained negative, we commenced maintenance treatment with N-acetylcysteine at 2.5 g in 250 mL 5% dextrose solution infused over 4 hours twice daily (100 mg/kg/day) from 26 June 2022 until viral clearance on 18 July 2022. Invasion of susceptible human cell by SARS-CoV-2 leads to the production of SARS-CoV-2 proteins in the endoplasmic reticulum (ER). Protective effect of N-acetylcysteine in a model of influenza infection in mice.
ISSN:1024-2708
2226-8707
DOI:10.12809/hkmj2210461