Effects of astaxanthin alone or its combination with diminazene aceturate on the survivability and haematological parameters of Trypanosoma brucei brucei–infected Wistar rats

• Published in: Comparative clinical pathology 2024-10, Vol.33 (5), p.745-756
• Main Authors: Kobo, P. I., Suleiman, M. M., Ayo, J. O., Lawal, I. A., Yaqub, L. S.
• Format: Article
• Language: English
• Subjects: Astaxanthin; Blood levels; Chemotherapy; Drug resistance; Erythrocytes; Hematology; Hemoglobin; Leukocytes (neutrophilic); Livestock; Medicine; Medicine & Public Health; Oncology; Original Article; Pathology; Protozoa; Toxicity; Trypanosoma brucei
• ISSN: 1618-565X; 1618-5641; 1618-565X
• DOI: 10.1007/s00580-024-03590-6

Trypanosomosis is a serious constraint to livestock productivity in sub-Saharan Africa. Chemotherapy which is the main means of control is unsatisfactory because of drug resistance and toxicity. Thus, the search for alternative antitrypanosomal agents has become imperative. The study was aimed at evaluating the effects of astaxanthin alone or in combination with diminazene aceturate (DZ) on parasitaemia and haematological parameters in Trypanosoma brucei brucei –infected Wistar rats. Eighty Wistar rats were divided into eight groups of ten rats each and treated as follows: I, DW (uninfected and treated with distilled water); II, S/OIL (uninfected and treated with soya oil); III, T (infected with 10 6 trypanosomes/mL); IV, PreA [pretreated with astaxanthin (100 mg/kg)] + T; V, PreA + T + DZ (3.5 mg/kg); VI, T + A (astaxanthin); VII, T + A + DZ; VIII, T + DZ. Parasitaemia was monitored daily, and blood was collected for evaluation of haematological parameters at the end of the experiment. Parasitaemia increased progressively in the T, PreA + T and T + A groups till the termination of the experiment, but was lower ( P