Post-metallation functionalization of the [(C^C)Au(P^P)] scaffold through a hydrothiolation reaction

Complex 1 [(C^C)Au(dppv)]PF 6 (dppv = cis -1,2-diphenylphosphinoethylene) is reported to react efficiently and selectively with aliphatic and aromatic thiols in the presence of a base. This methodology enables the smooth introduction of various functional groups on the [(C^C)Au(P^P)] + scaffold. Fun...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2024-10, Vol.53 (39), p.16144-16148
Main Authors: Yang, Jeannine, Soep, Clément, Forté, Jérémy, Dossmann, Héloïse, Bertrand, Benoît
Format: Article
Language:English
Subjects:
Chemical Sciences
Functional groups
Scaffolds
Thiols
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Summary:Complex 1 [(C^C)Au(dppv)]PF 6 (dppv = cis -1,2-diphenylphosphinoethylene) is reported to react efficiently and selectively with aliphatic and aromatic thiols in the presence of a base. This methodology enables the smooth introduction of various functional groups on the [(C^C)Au(P^P)] + scaffold. Functionalization of the [(C^C)Au(dppe)] + core through an efficient, chemoselective and functional group tolerant hydrothiolation reaction was achieved.
ISSN:1477-9226
1477-9234
DOI:10.1039/d4dt02092h