Exploring serum bile acids as potential noninvasive biomarkers for nonalcoholic fatty liver disease

BackgroundBile acids are vital regulators of liver metabolism, and their dysregulation is closely linked with the progression of nonalcoholic fatty liver disease (NAFLD). Profiling these bile acids may provide valuable diagnostic and prognostic markers for these conditions. This study aimed to evalu...

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Bibliographic Details
Published in:Egyptian Liver Journal 2024-10, Vol.14 (1), p.70-16
Main Authors: Basuni, Ashraf Abbass, Sweed, Dina, Elgazzar, Mohammed Fathey, Khalil, Ashraf
Format: Article
Language:English
Subjects:
Acids
Bile
Bile acids
Biomarkers
Biopsy
Cholesterol
Gallbladder diseases
Homeostasis
Inflammation
Insulin
Laboratories
Lipids
Liquid chromatography-mass spectrometry
Liver cirrhosis
Liver diseases
Metabolism
NAFLD
NASH
Nonalcoholic fatty liver disease
Nonalcoholic steatohepatitis
Pathogenesis
Ultrasonic imaging
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Summary:BackgroundBile acids are vital regulators of liver metabolism, and their dysregulation is closely linked with the progression of nonalcoholic fatty liver disease (NAFLD). Profiling these bile acids may provide valuable diagnostic and prognostic markers for these conditions. This study aimed to evaluate bile acid profiles in NAFLD patients and assess their potential as biomarkers for diagnosing and predicting disease progression. Serum levels of 14 bile acids were measured in 25 normal healthy controls (NHC), 35patients with metabolic dysfunction–associated steatotic liver disease (MASLD), and 40 patients with NASH, categorized by the NAFLD Activity Score (NAS). Quantification was performed using high-performance liquid chromatography-tandem mass spectrometry (HPLC–MS/MS).ResultsPrimary unconjugated bile acids, CA and CDCA, along with conjugated acids GCA, GCDCA, TCA, and TCDCA, were significantly elevated in both MASLD and NASH compared to NHC (all p 
ISSN:2090-6218
2090-6226
DOI:10.1186/s43066-024-00378-9